Hormonal Aspects of Meniere's Disease on the Basis of Clinical and Experimental Studies

被引:43
作者
Takeda, Taizo [1 ]
Takeda, Setsuko [1 ]
Kakigi, Akinobu [1 ,2 ]
Okada, Teruhiko [3 ]
Nishioka, Rie [1 ]
Taguchi, Daizo [1 ,4 ]
Nishimura, Masahiko [1 ,5 ]
Nakatani, Hiroaki [1 ]
机构
[1] Kochi Med Sch, Dept Otolaryngol, Kochi, Japan
[2] Univ Tokyo, Fac Med, Dept Otolaryngol, Tokyo 113, Japan
[3] Kochi Med Sch, Dept Anat, Kochi, Japan
[4] Tottori Univ, Fac Med, Div Otolaryngol Head & Neck Surg, Tottori 680, Japan
[5] Osaka Univ, Grad Sch Med, Dept Otolaryngol, Osaka, Japan
来源
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2009年 / 71卷
关键词
Vasopressin; Endolymphatic hydrops; Aquaporin; Vasopressin type 2 receptor; V-2; antagonist; Meniere's disease; RECEPTOR MESSENGER-RNAS; ANTI-DIURETIC HORMONE; INNER-EAR; ENDOLYMPHATIC HYDROPS; STRIA VASCULARIS; VASOPRESSIN V2; WATER CHANNELS; RAT; AQUAPORIN-2; EXPRESSION;
D O I
10.1159/000265113
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Conclusions: Endolymph homeostasis is thought to be mediated by the vasopressin-aquaporin-2 (VP-AQP2) system in the inner ear. Endolymphatic hydrops, the morphological characteristics of Meniere's disease (MD), seems to reflect the malregulation of the VP-AQP2 system in inner ear fluid. The elevation of plasma vasopressin (p-VP) level, which is often observed in MD and its related diseases, might be one of the causative factors underlying these diseases. Purpose of Review: Review of the role of the VP-AQP2 system in the inner ear fluid homeostasis and in the formation and development of endolymphatic hydrops. Recent Clinical and Experimental Findings: A clinical survey has revealed that the p-VP level is often elevated in MD and its related diseases and that the increase in the p-VP level was closely linked to vertigo attacks in MD. Experimental studies have revealed that proteins and mRNAs of aquaporin-2 and vasopressin type 2 receptor were expressed in the stria vascularis of the cochlea and the epithelium of the endolymphatic sac, and that the volume of the endolymphatic compartment was mediated by the activity of the VP-AQP2 system in the inner ear. Copyright (C) 2010 S. Karger AG, Basel
引用
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页码:1 / 9
页数:9
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