Twisting: A quantity describing the topological relation of two peptide fragments in protein structures

被引：0

作者：

Zeng, ZH ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

来源：

JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY | 2004年 / 3卷 / 04期

基金：

中国国家自然科学基金;

关键词：

protein structure; protein topology; protein folding; knot and braid;

D O I：

10.1142/S0219633604001173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for analyzing the topological relation of any two peptide fragments in a protein structure is given by making analogy of the two fragments with a braid. Knotted relations are analyzed by calculating polynomials for the two fragments separately and for the two as a whole, respectively. Twisting is calculated from the writhe number, which is a measure to the internal relative rotation during formation of the protein structure. Statistical analysis on the internal rotations of all known structures found that the relative rotation like a one-dimensional random walk with decreasing step lengths.

引用

页码：521 / 526

页数：6

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