Novel benzimidazole-pyrimidine conjugates as potent antitumor agents

被引：119

作者：

Abdel-Mohsen, Heba T. ^{[1
]}

Ragab, Fatma A. F. ^{[2
]}

Ramla, Mostafa M. ^{[1
]}

El Diwani, Hoda I. ^{[1
]}

机构：

[1] Natl Res Ctr, Div Pharmaceut & Drug Ind Res, Dept Chem Nat & Microbial Prod, Cairo, Egypt

[2] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 06期

关键词：

Synthesis; Benzimidazole; Pyrimidine; Antitumor activity; DERIVATIVES; INHIBITORS; GROWTH; CYTOTOXICITY; BMS-536924; ANALOGS; IGF-1R;

D O I：

10.1016/j.ejmech.2010.02.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs.

引用

页码：2336 / 2344

页数：9

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