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The CRISPR-Cas9 system in Neisseria spp
被引:11
|作者:
Zhang, Yan
[1
,2
]
机构:
[1] Univ Massachusetts, Sch Med, RNA Therapeut Inst, Worcester, MA 01605 USA
[2] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
来源:
PATHOGENS AND DISEASE
|
2017年
/
75卷
/
04期
关键词:
CRISPR-Cas9;
genome engineering;
RNA-guided adaptive interference;
Neisseria spp;
CAS ADAPTIVE IMMUNITY;
RNA-GUIDED ENDONUCLEASE;
TARGET DNA RECOGNITION;
ESCHERICHIA-COLI;
NATURAL TRANSFORMATION;
SPACER ACQUISITION;
BACTERIAL IMMUNITY;
CRISPR/CAS SYSTEM;
GENE-REGULATION;
FOREIGN DNA;
D O I:
10.1093/femspd/ftx036
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Bacteria and archaea possess numerous defense systems to combat viral infections and other mobile genetic elements. Uniquely among these, CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR associated) provides adaptive genetic interference against foreign nucleic acids. Here we review recent advances on the CRISPR-Cas9 system in Neisseria spp, with a focus on its biological functions in genetic transfer, its mechanistic features that establish new paradigms and its technological applications in eukaryotic genome engineering.
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页数:10
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