In situ monitoring of vapour-induced assembly of pharmaceutical cocrystals using a benchtop powder X-ray diffractometer

被引：28
|
作者：
Huskic, Igor [1 ]
Christopherson, Jan-Constantin [1 ]
Uzarevic, Krunoslav [1 ,2 ]
Friscic, Tomislav [1 ]
机构：
[1] McGill Univ, Dept Chem, 801 Sherbrooke St W, Montreal, PQ H3A 0B8, Canada
[2] Rudjer Boskovic Inst, Bijenicka 54, Zagreb 10000, Croatia
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 29期
关键词：
REAL-TIME; CO-CRYSTAL; CARBAMAZEPINE; CHEMISTRY; POLYMORPH; MECHANOCHEMISTRY; TRANSFORMATIONS;
D O I：
10.1039/c6cc01583b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe a simple setup for in situ continuous monitoring of vapour-induced transformations of organic solids using a benchtop powder X-ray diffractometer. Proof-of-principle application of this setup to model pharmaceutical cocrystals reveals complex reactivity, transformations of reaction intermediates within minutes, and a simple route to the rarely observed monoclinic form of the pharmaceutical cocrystal of carbamazepine and saccharin.
引用
收藏
页码：5120 / 5123
页数：4
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