Diastereoselectivity in the alkylations of bicyclic piperidinones

被引：7

作者：

Mills, CE ^{[1
]}

Heightman, TD ^{[1
]}

Hermitage, SA ^{[1
]}

Moloney, MG ^{[1
]}

Woods, GA ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)10694-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of substituted [4.3.0] bicyclic lactams derived from 6-oxo-2-hydroxymethylpiperidine is described. The enolate derived from these systems can be alkylated with a range of reactive electrophiles; the diastereoselectivity which can be achieved depends on the substitution pattern of the oxazolidine ring system and the nature of the alkylating reagent, and can vary from 1:1 to as much as 10:1. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1025 / 1028

页数：4

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