Resolution of chronic inflammatory disease: universal and tissue-specific concepts

被引：306
作者：
Schett, Georg [1 ,2 ]
Neurath, Markus F. [2 ,3 ]
机构：
[1] Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany
[2] Univ Klinikum Erlangen, D-91054 Erlangen, Germany
[3] Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 1, D-91054 Erlangen, Germany
来源：
NATURE COMMUNICATIONS | 2018年 / 9卷
关键词：
INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; SUCCINATE-DEHYDROGENASE; APOPTOTIC CELLS; MOUSE MODELS; MACROPHAGES; EOSINOPHILS; RESPONSES; RECEPTOR; PHOSPHATIDYLSERINE;
D O I：
10.1038/s41467-018-05800-6
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss the resolution of inflammation in both a biological and translational context. We introduce the concept of impaired resolution leading to diseases like rheumatoid arthritis, Crohn's disease, and asthma, as well as the cellular and molecular components that contribute to resolution of joint, gut, and lung inflammation, respectively. Finally, we discuss potential intervention strategies for fostering the resolution process, and their implications for the therapy of inflammatory diseases.
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页数：8
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