Invasive fungal rhinosinusitis in immunocompromised patients

Introduction: Invasive fungal rhinosinusitis (IFR) is one of the most important causes of morbidity and mortality in immunocompromised patients, principally those with cellular immunodeficiency, with mortality ranging from 50 to 80%. Prophylaxis and early diagnosis increase the chances of successful treatment. Study design: Clinical prospective randomized study. Aim: To present cases of IFR and to compare them with data reported in the literature. Material and methods: Analysis of eleven cases of IFR confirmed by pathologist examination. Results: Aspergillus was found to be the most prevalent pathogen. Symptoms ranged from high fever in most cases to nasal discharge, ulceration of the nasal mucosa, headache and periorbital edema. Conclusion: The combination of amphotericin B and endoscopic surgery, associated or not with Caldwell-Luc surgery, showed good results. The use of liposomal amphotericin B also presented a satisfactory outcome.