Wanted: regulatory SNPs

被引:89
作者
Hudson, TJ [1 ]
机构
[1] McGill Univ, Montreal, PQ H3A 1A4, Canada
[2] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada
关键词
D O I
10.1038/ng0403-439
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Reliable identification of genetic variants that affect gene regulation is still a challenge in genomics and is expected to have an important role in the molecular characterization of complex traits. A new study describes a robust functional assay that detects the presence of cis-acting polymorphisms that regulate gene transcription.
引用
收藏
页码:439 / 440
页数:2
相关论文
共 14 条
[1]   Genetic dissection of transcriptional regulation in budding yeast [J].
Brem, RB ;
Yvert, G ;
Clinton, R ;
Kruglyak, L .
SCIENCE, 2002, 296 (5568) :752-755
[2]   Characterization of single-nucleotide polymorphisms in coding regions of human genes [J].
Cargill, M ;
Altshuler, D ;
Ireland, J ;
Sklar, P ;
Ardlie, K ;
Patil, N ;
Lane, CR ;
Lim, EP ;
Kalyanaraman, N ;
Nemesh, J ;
Ziaugra, L ;
Friedland, L ;
Rolfe, A ;
Warrington, J ;
Lipshutz, R ;
Daley, GQ ;
Lander, ES .
NATURE GENETICS, 1999, 22 (03) :231-238
[3]   Natural variation in human gene expression assessed in lymphoblastoid cells [J].
Cheung, VG ;
Conlin, LK ;
Weber, TM ;
Arcaro, M ;
Jen, KY ;
Morley, M ;
Spielman, RS .
NATURE GENETICS, 2003, 33 (03) :422-425
[4]   Detection of regulatory variation in mouse genes [J].
Cowles, CR ;
Hirschhorn, JN ;
Altshuler, D ;
Lander, ES .
NATURE GENETICS, 2002, 32 (03) :432-437
[5]   High-resolution haplotype structure in the human genome [J].
Daly, MJ ;
Rioux, JD ;
Schaffner, SE ;
Hudson, TJ ;
Lander, ES .
NATURE GENETICS, 2001, 29 (02) :229-232
[6]   The structure of haplotype blocks in the human genome [J].
Gabriel, SB ;
Schaffner, SF ;
Nguyen, H ;
Moore, JM ;
Roy, J ;
Blumenstiel, B ;
Higgins, J ;
DeFelice, M ;
Lochner, A ;
Faggart, M ;
Liu-Cordero, SN ;
Rotimi, C ;
Adeyemo, A ;
Cooper, R ;
Ward, R ;
Lander, ES ;
Daly, MJ ;
Altshuler, D .
SCIENCE, 2002, 296 (5576) :2225-2229
[7]   Long human-mouse sequence alignments reveal novel regulatory elements: A reason to sequence the mouse genome [J].
Hardison, RC ;
Oeltjen, J ;
Miller, W .
GENOME RESEARCH, 1997, 7 (10) :959-966
[8]   In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading [J].
Knight, JC ;
Keating, BJ ;
Rockett, KA ;
Kwiatkowski, DR .
NATURE GENETICS, 2003, 33 (04) :469-475
[9]   Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction [J].
Ozaki, K ;
Ohnishi, Y ;
Iida, A ;
Sekine, A ;
Yamada, R ;
Tsunoda, T ;
Sato, H ;
Sato, H ;
Hori, M ;
Nakamura, Y ;
Tanaka, T .
NATURE GENETICS, 2002, 32 (04) :650-654
[10]   Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease [J].
Rioux, JD ;
Daly, MJ ;
Silverberg, MS ;
Lindblad, K ;
Steinhart, H ;
Cohen, Z ;
Delmonte, T ;
Kocher, K ;
Miller, K ;
Guschwan, S ;
Kulbokas, EJ ;
O'Leary, S ;
Winchester, E ;
Dewar, K ;
Green, T ;
Stone, V ;
Chow, C ;
Cohen, A ;
Langelier, D ;
Lapointe, G ;
Gaudet, D ;
Faith, J ;
Branco, N ;
Bull, SB ;
McLeod, RS ;
Griffiths, AM ;
Bitton, A ;
Greenberg, GR ;
Lander, ES ;
Siminovitch, KA ;
Hudson, TJ .
NATURE GENETICS, 2001, 29 (02) :223-228