Interleukin-1 receptor antagonist gene therapy for arthritis

被引：0
|
作者：
Krishnan, BR [1 ]
机构：
[1] Pfizer Inc, Cent Res, AH Biol Discovery, Groton, CT 06340 USA
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 1999年 / 1卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Rheumatoid arthritis (RA) is a crippling, autoimmune disease, and is characterized by inflammation and destruction of joint tissue. Interleukin-1 (IL-1) has been identified as a key proinflammatory cytokine responsible for inflammation. One of the mechanisms of regulation of activity of IL-1 is IL-1 receptor antagonist (IL-1ra)-mediated: IL-1RA competes with IL-1 for binding to the IL-1 receptor. Significant progress has been made in the potential application of IL-1ra gene therapy for the treatment of arthritis. Various vectors have been tested for the delivery of the IL-1ra gene to the intra-articular region. Recent studies in humans have provided encouraging prospects for IL-1ra-mediated arthritis gene therapy.
引用
收藏
页码：454 / 457
页数：4
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