Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

被引：27

作者：

Moraga, Ana ^{[1
,2
]}

Gomez-Vallejo, Vanessa ^{[3
]}

Isabel Cuartero, Maria ^{[1
,2
]}

Szczupak, Boguslaw ^{[4
]}

San Sebastian, Eneko ^{[4
]}

Markuerkiaga, Irati ^{[4
]}

Pradillo, Jesus M. ^{[1
,2
]}

Higuchi, Makoto

Llop, Jordi ^{[3
]}

Angeles Moro, Maria ^{[1
,2
]}

Martin, Abraham ^{[4
]}

Lizasoain, Ignacio ^{[1
,2
]}

机构：

[1] Univ Complutense Madrid, Fac Med, Dept Farmacol, Unidad Invest Neurovasc, E-28040 Madrid, Spain

[2] Inst Invest Hosp 12 Octubre I 12, Madrid, Spain

[3] BiomaGUNE, CIC, Mol Imaging Unit, Radiochem, San Sebastian, Guipuzcoa, Spain

[4] CIC BiomaGUNE, Mol Imaging Unit, Edificio Empresarial C,P Miramon 182, San Sebastian 2009, Guipuzcoa, Spain

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 04期

关键词：

Positron emission tomography; magnetic resonance imaging; middle cerebral artery occlusion; cerebral ischemia; toll-like receptor 4; 3 '-deoxy-3 '-[F-18]fluorothymidine; C-11]PK11195; T2W-MRI; EXPERIMENTAL STROKE; INDUCED NEUROINFLAMMATION; BENZODIAZEPINE-RECEPTOR; MICE; INJURY; PET; NEUROGENESIS; INDUCTION; MICROGLIA; MIGRATION;

D O I：

10.1177/0271678X15627657

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[F-18]fluorothymidine and [C-11]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+) and TLR4(-/-) mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[F-18]fluorothymidine and [C-11]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-) mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

引用

页码：702 / 708

页数：7

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