Inhibitory avoidance memory deficit induced by scopolamine: Interaction of cholinergic and glutamatergic systems in the ventral tegmental area

被引:27
作者
Mahmoodi, Gelavij [2 ]
Ahmadi, Shamseddin [3 ]
Pourmotabbed, Ali [4 ]
Oryan, Shahrbanoo [2 ,5 ]
Zarrindast, Mohammad Reza [1 ,2 ,6 ,7 ,8 ,9 ]
机构
[1] Univ Tehran Med Sci, Dept Pharmacol, Sch Med, Tehran, Iran
[2] Islamic Azad Univ, Dept Biol, Sci & Res Branch, Tehran, Iran
[3] Univ Kurdistan, Dept Biol Sci & Biotechnol, Fac Sci, Sanandaj, Iran
[4] Kermanshah Univ Med Sci, Dept Physiol, Kermanshah, Iran
[5] Tarbiat Moallem Univ, Dept Biol, Fac Sci, Tehran, Iran
[6] Univ Tehran Med Sci, Dept Neurosci, Sch Adv Med Technol, Tehran, Iran
[7] Univ Tehran Med Sci, Iranian Natl Ctr Addict Studies, Tehran, Iran
[8] Inst Studies Fundamental Sci IPM, Sch Cognit Sci, Tehran, Iran
[9] Inst Cognit Sci Studies, Tehran, Iran
关键词
Scopolamine; NMDA; MK-801; VTA; Consolidation; Retrieval; Rat; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; HIPPOCAMPAL-FORMATION; PREFRONTAL CORTEX; MOLECULAR-MECHANISMS; DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; NMDA RECEPTORS; MODULATION;
D O I
10.1016/j.nlm.2010.04.004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Interaction of cholinergic and glutamatergic inputs in the ventral tegmental area (VTA) influencing a learned behavior is a topic of great interest. In the present study the effect of intra-VTA administration of a nonselective muscarinic acetylcholine antagonist, scopolamine, and N-methyl-n-aspartate (NMDA) receptor agents by themselves as well as their interactions on consolidation and retrieval of inhibitory avoidance (IA) memory have been investigated. A step-through inhibitory avoidance task was used for memory assessment in male Wistar rats. The results showed that intra-VTA administration of scopolamine (1 and 2 mu g/rat) and NMDA receptor antagonist, MK-801 (0.75 and 1 mu g/rat) immediately after training, impaired consolidation of IA memory. Interestingly, co-administration of an ineffective dose of MK-801 (0.5 mu g/rat) with ineffective doses of scopolamine (0.25 and 0.5 mu g/rat) significantly decreased the consolidation process. Post-training intra-VTA injections of NMDA (0.001 and 0.01 mu g/rat) had no effects by itself, whereas its co-administration with scopolamine (2 mu g/rat) prevented the effect of the later drug. The results also showed that pre-test intra-VTA administration of scopolamine (3 and 4 mu g/rat) and MK-801 (1 and 2 mu g/rat) impaired retrieval of the IA memory. Moreover, co-administration of an ineffective dose of MK-801 (0.5 mu g/rat) with ineffective doses of scopolamine (1 and 2 mu g/rat) increasingly reduced the retrieval of the IA memory. On the contrary to its post-training treatment, pre-test administration of NMDA either alone or in combination with scopolamine caused no significant effect on retrieval of IA memory. It can be concluded that muscarinic acetylcholine and NMDA glutamate receptors in the VTA are involved in the mechanism(s) underlying consolidation and retrieval of the IA memory. (c) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:83 / 90
页数:8
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