Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival

被引：12

作者：

Ciccone, R

Mariani, F

Cavone, A

Persichini, T

Venturini, G

Ongini, E

Colizzi, V

Colasanti, M

机构：

[1] Univ Roma Tre, Dept Biol, I-00146 Rome, Italy

[2] CNR, Inst Neurobiol & Mol Med, Rome, Italy

[3] Univ Roma Tre, Dept Biol, Rome, Italy

[4] Nicox Res Inst, Milan, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2299-2302.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.

引用

收藏

页码：2299 / 2302

页数：4

相关论文

共 18 条

[1] Nitric oxide and virus infection [J].

Akaike, T ;

Maeda, H .

IMMUNOLOGY, 2000, 101 (03) :300-308

[2] The clinical use of fluoroquinolones for the treatment of mycobacterial diseases [J].

Alangaden, GJ ;

Lerner, SA .

CLINICAL INFECTIOUS DISEASES, 1997, 25 (05) :1213-1221

[3] What is the role of nitric oxide in murine and human host defense against tuberculosis? Current knowledge [J].

Chan, ED ;

Chan, J ;

Schluger, NW .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (05) :606-612

[4]

Clark IA, 1996, ADV PARASIT, V37, P1, DOI 10.1016/S0065-308X(08)60218-3

[5] S-nitrosylation of viral proteins: Molecular bases for antiviral effect of nitric oxide [J].

Colasanti, M ;

Persichini, T ;

Venturini, G ;

Ascenzi, P .

IUBMB LIFE, 1999, 48 (01) :25-31

[6] A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis [J].

Couture, M ;

Yeh, SR ;

Wittenberg, BA ;

Wittenberg, JB ;

Ouellet, Y ;

Rousseau, DL ;

Guertin, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11223-11228

[7] NO-aspirins: a class of new antiinflammatory and antithrombotic agents [J].

del Soldato, P ;

Sorrentino, R ;

Pinto, A .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (08) :319-323

[8] Regulation of hmp gene transcription in Mycobacterium tuberculosis:: Effects of oxygen limitation and nitrosative and oxidative stress [J].

Hu, YM ;

Butcher, PD ;

Mangan, JA ;

Rajandream, MA ;

Coates, ARM .

JOURNAL OF BACTERIOLOGY, 1999, 181 (11) :3486-3493

[9]

Huttunen K, 2001, INHAL TOXICOL, V13, P977

[10] Mycobacteriocidal action of exogenous nitric oxide [J].

Long, R ;

Light, B ;

Talbot, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) :403-405