A Novel Diastereoselective Multicomponent Cascade Reaction

被引：50

作者：

Kriis, Kadri ^{[1
]}

Ausmees, Kerti ^{[1
]}

Pehk, Tonis ^{[2
]}

Lopp, Margus ^{[1
]}

Kanger, Tonis ^{[1
]}

机构：

[1] Tallinn Univ Technol, Dept Chem, EE-12618 Tallinn, Estonia

[2] NICPB, EE-12618 Tallinn, Estonia

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 10期

关键词：

STEREOSELECTIVE-SYNTHESIS; MICHAEL ADDITION; DOMINO REACTIONS; ORGANOCATALYSTS; ISONITRILE;

D O I：

10.1021/ol1005714

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel multicomponent cascade reaction led to the formation of a strained 3-azabicyclo[3.2.0]heptane derivative 4. The unstable ester 4 was reduced in a one-pot procedure to a stable alcohol 6. The formation of the bicyclic product is highly diastereoselective, predominantly affording one diastereoisomer. The obtained azabicycloheptanes are important pharmacophores.

引用

收藏

页码：2230 / 2233

页数：4

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