Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer

被引：32

作者：

Gu, Ying ^{[1
]}

Ma, Chenyun ^{[2
]}

Zou, Jue ^{[3
]}

Zhu, Yi ^{[1
]}

Yang, Rong ^{[1
]}

Xu, Yan ^{[1
]}

Zhang, Yu ^{[1
]}

机构：

[1] Shanghai Univ TCM, Peoples Hosp 7, Dept Obstet & Gynaecol, Shanghai 200137, Peoples R China

[2] Shanghai Univ TCM, Peoples Hosp 7, Clin Lab, Shanghai 200137, Peoples R China

[3] Shanghai Univ TCM, Peoples Hosp 7, Dept Pathol, Shanghai 200137, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 17期

关键词：

high-risk human papillomaviruses; cervicitis; cervical intraepithelial neoplasia grade 1 to 3; invasive squamous cell carcinoma; SCREENING GUIDELINES; HPV; METAANALYSIS; PERFORMANCE; PREVENTION; CYTOLOGY; VACCINE;

D O I：

10.18632/oncotarget.8262

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A complete understanding of the natural history of infection with high-risk human papillomaviruses (HPVs) in cervical cancer requires data from regional and ethnic studies. The prevalence of high-risk HPVs was evaluated retrospectively in 2040 patients with cervicitis, 239 with cervical intraepithelial neoplasia grade 1 (CIN1), 242 with CIN2/3, and 42 patients with invasive squamous cell carcinoma (SCC) based on data from patients who visited our hospital between May 2013 and May 2015. The rates of high-risk HPV infection in patients with cervicitis, CIN1, CIN2/3, and invasive SCC were 40.8%, 74.9%, 70.2%, and 83.3%, respectively. The three most dominant HPV genotypes were HPV16, 58, and 52. HPV16 and HPV58 positivity in cervicitis, CIN1, CIN2/3, and SCC patients were 20.9% and 16.4%, 19.0% and 20.1%, 44.1% and 23.5%, and 60.0% and 31.4%, respectively. Compared to cervicitis, the odds ratios (ORs) for CIN2/3 in HPV16- and HPV58-positive patients were 2.99 (95% confidence interval [CI]: 1.32-4.33) and 1.56 (1.11-3.21), respectively; for SCC, the corresponding values were 5.68 (2.31-7.893) and 2.33 (1.41-3.87). Further identifying of carcinogenic HPVs and a fully aware of regional differences in HPV genotype distribution are tasks of top priority for cervical cancer control and prevention.

引用

页码：24656 / 24663

页数：8

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