The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population

被引:8
作者
Sigit, Fathimah S. [1 ,2 ]
Trompet, Stella [3 ]
Tahapary, Dicky L. [2 ,4 ]
Sartono, Erliyani [5 ]
van Dijk, Ko Willems [6 ,7 ]
Yazdanbakhsh, Maria [5 ]
Supali, Taniawati [8 ]
Smit, Johannes W. A. [7 ,9 ]
Rosendaal, Frits R. [1 ]
de Mutsert, Renee [1 ]
机构
[1] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[2] Univ Indonesia, Fac Med, Indonesian Med Educ & Res Inst, Metab Cardiovasc & Aging Cluster, Jalan Salemba Raya 6, Jakarta 10430, Indonesia
[3] Leiden Univ, Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[4] Univ Indonesia, Fac Med, Dr Cipto Mangunkusumo Natl Referral Hosp, Dept Internal Med, Jalan Salemba Raya 6, Jakarta 10430, Indonesia
[5] Leiden Univ, Med Ctr, Dept Parasitol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[6] Leiden Univ, Med Ctr, Dept Human Genet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[7] Leiden Univ, Med Ctr, Sect Endocrinol, Dept Internal Med, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[8] Univ Indonesia, Fac Med, Dr Cipto Mangunkusumo Natl Referral Hosp, Dept Parasitol, Jalan Salemba Raya 6, Jakarta 10430, Indonesia
[9] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands
关键词
Leptin; Adiponectin; Total body fat; The metabolic syndrome (MetS); Asian; Western; BODY-MASS INDEX; INSULIN-RESISTANCE; ADIPOSE-TISSUE; LEPTIN/ADIPONECTIN RATIO; VISCERAL FAT; ABDOMINAL OBESITY; ATHEROSCLEROSIS; INFLAMMATION; MARKERS; ASIANS;
D O I
10.1016/j.numecd.2021.05.012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aims: At the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of the adipocyte-derived hormones leptin and adiponectin plays a role and investigated the associations of the two hormones with the metabolic syndrome (MetS) in an Indonesian and a Dutch population. Methods and results: We performed cross-sectional analyses of the Netherlands Epidemiology of Obesity Study (n = 6602) and the SUGAR Scientific Programme Indonesia-Netherlands Study (n = 1461). We examined sex-stratified associations of leptin and adiponectin with MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) leptin (mcg/L) were 4.7 (6.0) in Indonesian men, 18.6 (12.0) in Indonesian women, 9.1 (7.7) in Dutch men, and 23.4 (17.4) in Dutch women. The mean (SD) adiponectin (mg/L) were 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), and 11.3 (4.9), respectively. Within the same BMI category, leptin concentrations were similar in the two populations, whereas adiponectin was lower in the Indonesian population. Per SD of leptin, adjusted prevalence odds ratios (ORs, 95%CI) of MetS were 0.9 (0.6-1.2) in Indonesian men, 1.1 (0.9-1.4) in Indonesian women, 2.2 (1.6-2.8) in Dutch men, and 1.2 (1.0-1.5) in Dutch women. Per SD of adiponectin, the ORs were 0.9 (0.7-1. 2), 0.8 (0.7-1.0), 0.6 (0.6-0.8), and 0.4 (0.4-0.5), respectively. Conclusions: Despite lower adiponectin levels, adiponectin was not related to the MetS in the Indonesian population and can not explain their increased cardiometabolic risk at the same BMI. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:2426 / 2435
页数:10
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