PEGylated copper(II)-chelated polydopamine nanocomposites for photothermal-enhanced chemodynamic therapy against tumor cells

被引：12

作者：

Zhang, Qiuye ^{[1
]}

Wang, Jingjing ^{[1
,2
]}

Xu, Luen ^{[1
]}

Lu, Shi-Yu ^{[1
,2
]}

Yang, Huawei ^{[2
]}

Duan, Yifan ^{[1
]}

Yang, Qiang ^{[1
]}

Qiu, Mengfan ^{[1
]}

Chen, Chunmei ^{[1
]}

Zhao, Sheng ^{[1
]}

Liu, Xiaohong ^{[3
,4
]}

Liu, Hui ^{[1
]}

机构：

[1] Southwest Univ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China

[2] Peking Univ, Beijing Innovat Ctr Engn Sci & Adv Technol, Beijing Key Lab Magnetoelect Mat & Devices, Dept Mat Sci & Engn,Coll Engn, Beijing, Peoples R China

[3] Chongqing Youth Vocat & Tech Coll, Chongqing 400712, Peoples R China

[4] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2021年 / 138卷 / 40期

基金：

中国国家自然科学基金;

关键词：

biomaterials; nanostructured polymers; thermal properties; self‐ assembly; NANOPARTICLES; NANOPLATFORM; CHEMOTHERAPY; NANOCOMPLEX; GENERATION;

D O I：

10.1002/app.51172

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Photothermal-enhanced chemodynamic therapy is a novel and promising strategy for effective tumor treatment. Herein, a kind of polydopamine (PDA)-based nanoplatform is reported for photothermal-enhanced chemodynamic therapy against tumor cells. PDA nanoparticles (NPs) were prepared through the self-polymerization method, which were subsequently chelated with Cu2+ and linked with poly(ethylene glycol) (PEG) chains, finally obtaining PDA-Cu(II)-PEG NPs. The fabricated PDA-Cu(II)-PEG NPs were uniform in shape with a narrow polydispersity. They can firstly react with glutathione (GSH) to generate Cu+, inducing GSH depletion meanwhile. The formed Cu+ could catalyze H2O2 to produce hydroxyl radicals (OH) via a Fenton-like reaction. The formed PDA-Cu(II)-PEG NPs displayed good photothermal conversion efficiency and photothermal stability. They can be internalized by 4T1 cells effectively. Under near-infrared light irradiation, PDA-Cu(II)-PEG NPs can generate hyperthermia and OH for photothermal/chemodynamic therapy against tumor cells.

引用

页数：9

共 40 条

[11] PEGylated polypyrrole-gold nanocomplex as enhanced photothermal agents against tumor cells [J].