4-hydroxy-17a-oxa-17a-homoandrost-4-ene-3,17-dione

被引：5

作者：

Paixao, JA ^{[1
]}

Andrade, LCR

de Almeida, MJ

da Silva, EJT

Melo, MLSE

Neves, ASC

机构：

[1] Univ Coimbra, Fac Ciencias & Tecnol, Dept Fis, P-3000 Coimbra, Portugal

[2] Univ Coimbra, Fac Farm, Quim Farmaceut Lab, P-3000 Coimbra, Portugal

[3] Univ Coimbra, Fac Farm, Quim Farmaceut Lab, Ctr Estudos Farmaceut, P-3000 Coimbra, Portugal

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1998年 / 54卷

关键词：

D O I：

10.1107/S0108270197012316

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dihedral angles between ring planes of the title compound, C19H26O4, a D-ring lactone, indicate a slightly curved molecular profile. All ring junctions are trans. A hydrogen bond between the hydroxyl group of ring A and the carbonyl group of ring D links the molecules head-to-tail in helical chains parallel to the 2(1) screw axis along a.

引用

页码：92 / 93

页数：2

共 13 条

[1] Novel approach to the synthesis of the aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4-OHA) [J].

daSilva, EJT ;

Melo, MLSE ;

Neves, ASC .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (14) :1649-1650

[2]

DASILVA EJT, 1997, UNPUB J CHEM SOC P1

[3]

Duax W.L., 1975, Atlas of Steroid Structure, V1

[4]

Enraf-Nonius, 1989, CAD 4 SOFTW VERS 5 0

[5]

FRENZ BA, 1985, ENRAF NONIUS SDP PLU

[6] STRUCTURE OF 4-HYDROXY-4-ANDROSTENE-3,17-DIONE [J].

GRIFFIN, JF ;

STRONG, PD ;

DUAX, WL ;

BRODIE, AMH ;

BRODIE, HJ .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1980, 36 (JAN) :201-203

[7] (14 alpha,22E)-14-hydroxyergosta-4,7,22-triene-3,6-dione, C28H40O3 [J].

Honda, T ;

Fujii, I ;

Hirayama, N ;

Ishikawa, D ;

Kawagishi, H ;

Song, KS ;

Yoo, ID .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1996, 52 :1550-1552

[8]

Johnson C. K., 1976, ORNL5138

[9]

MAIN B, 1982, MULTAN182 SYSTEM COM

[10] 17-BETA-HYDROXY-4,14-ESTRADIEN-3-ONE [J].

ROHRER, DC ;

DUAX, WL ;

SEGALOFF, A .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS, 1978, 34 (SEP) :2915-2917

← 1 2 →