Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

被引：7

作者：

Cavalcante, Jose Roosevelt ^{[1
]}

Sampaio, Joao Paulo Aguiar ^{[1
]}

Alves Maia Filho, Joao Tarcisio ^{[1
]}

Vieira, Renato Braga ^{[1
]}

Eleuterio Junior, Jose ^{[1
]}

Pereira Lima Junior, Roberto Cesar ^{[1
]}

Ribeiro, Ronaldo Albuquerque ^{[1
]}

Carvalho Almeida, Paulo Roberto ^{[1
]}

机构：

[1] Fed Univ Ceara UFC, Dept Pathol & Forens Med, Pathol Lab, Fortaleza, Ceara, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2014年 / 29卷 / 10期

关键词：

Cadherins; Immunohistochemistry; Cervical Intraepithelial Neoplasia; Neoplasms squamous cell; Uterine Cervical Neoplasms; EPITHELIAL-MESENCHYMAL TRANSITION; SQUAMOUS INTRAEPITHELIAL LESIONS; PROGNOSTIC MARKER; EXPRESSION; CANCER; CELL; ADHESION; CATENIN;

D O I：

10.1590/S0102-8650201400160007

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL-52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.

引用

页码：667 / 674

页数：8

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