Carboplatin Use in Pregnancy for Stage IB3 Cervical Cancer: Case Report and Review of the Literature

被引：5
作者：
Rabaiotti, Emanuela [1 ]
Girardelli, Serena [1 ]
Valsecchi, Luca [1 ]
Bergamini, Alice [1 ]
Petrone, Micaela [1 ]
Mangili, Giorgia [1 ]
Candiani, Massimo [1 ]
机构：
[1] IRCCS Osped San Raffaele, Obstet & Gynecol Dept, Milan, Italy
来源：
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY | 2020年 / 9卷 / 03期
关键词：
pregnancy; cervical carcinoma; neoadjuvant chemotherapy; NEOADJUVANT CHEMOTHERAPY; PACLITAXEL; CISPLATIN; WOMEN;
D O I：
10.1089/jayao.2019.0118
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Locally advanced stage cervical cancer diagnosed during pregnancy is a clinical challenge and requires skill in balancing maternal management, fetal care, and oncological treatment. Cisplatin has been routinely used as a first line agent for neoadjuvant chemotherapy in this situation, even though it has also recently been associated with fetal hearing loss. We report a case of stage IB3 cervical cancer diagnosed at 17 gestational weeks successfully treated with neoadjuvant chemotherapy using carboplatin and paclitaxel during pregnancy. Carboplatin is a valid alternative to cisplatin for advanced stage cervical carcinoma in a pregnant patient, in particular in view of the neonatal complications (primarily ototoxicity) that are associated with in utero cisplatin exposure.
引用
收藏
页码：445 / 448
页数：4
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