Maturation of human dendritic cells induced by the adjuvant cholera toxin: role of cAMP on chemokine receptor expression

被引：32
作者：
Gagliardi, MC [1 ]
De Magistris, MT [1 ]
机构：
[1] Ist Super Sanita, Lab Bacteriol & Med Mycol, I-00161 Rome, Italy
来源：
VACCINE | 2003年 / 21卷 / 9-10期
关键词：
cAMP; chemokine receptors; dendritic cells;
D O I：
10.1016/S0264-410X(02)00532-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cholera toxin (CT) is a very effective adjuvant for mucosal vaccination. It binds to cells through its B subunit and induces intracellular increase of cAMP through the A subunit. We previously showed that CT induces maturation of human dendritic cells (DCs) and this may account for its adjuvant property. Here, we investigated the role of the A subunit on DCs maturation by using forskolin, a cAMP inducer. The results show that although cAMP does not stimulate full maturation of DCs it induces upregulation of the chemokine receptors CXCR4 and CCR7. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：856 / 861
页数：6
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