In vitro cytotoxicity analysis of Zizyphus spina-christi stem bark extract on human cancer cell lines

被引：2
|
作者：
Rajendrasozhan, Saravanan [1 ]
Ads, Essam N. [2 ]
Abouzied, Amr S. [3 ,4 ]
Humaidi, Jamal R. [1 ]
机构：
[1] Univ Hail, Coll Sci, Dept Chem, Hail 55476, Saudi Arabia
[2] Zagazig Univ, Fac Sci, Mansoura 35522, Egypt
[3] Univ Hail, Coll Pharm, Dept Pharmaceut Chem, Hail 55476, Saudi Arabia
[4] Natl Org Drug Control & Res, Dept Pharmaceut Chem, Giza 35521, Egypt
来源：
BIOINFORMATION | 2021年 / 17卷 / 05期
关键词：
Anticancer; cytotoxic; phytochemicals; natural remedies; Zizyphus spina-christi; ACID;
D O I：
10.6026/97320630017583
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Zizyphus spina-christi (Rhamnaceae family) is an edible plant used in folk medicine. Therefore, it is of interest to report the cytotoxic effects of Z. spina-christi bark crude extract on human cell lines. Crude ethanol extract of Z. spina-christi bark was fractionated with increasing polarity (diethyl ether, chloroform, ethyl acetate and butanol fractions). The fractions were examined for their cytotoxicity against human colon cancer (HCT-116 and CACO-2), cervical cancer (HeLa and HEp-2), lung carcinoma (A-549), hepatocellular carcinoma (HepG-2), breast cancer (MCF-7) and prostate cancer (PC-3) cell lines using viability assay. Diethyl ether fraction of Z. spina-christi showed the highest cytotoxic effects among the four extracts of Z. spina-christi. The IC50 of diethyl ether fraction was 7.14, 11.2, 11.6, 15.4, 39.8, 42.2, 84.2 and 153.8 mu g/ml on HepG-2, A-549, CACO-2, HCT-116, MCF-7, PC-3, HeLa, and HEp-2 cell lines, respectively. Data shows that the diethyl ether fraction of Z. spina-christi showed effective cytotoxic effects in colon, lung and hepatocellular cancer cell lines.
引用
收藏
页码：583 / 592
页数：10
相关论文
共 50 条
  • [21] Isolation, Structure Elucidation and Antimicrobial Evaluation of Natural Pentacyclic Triterpenoids and Phytochemical Investigation of Different Fractions of Ziziphus spina-christi (L.) Stem Bark Using LCHRMS Analysis
    Ads, Essam N.
    Hassan, Syed, I
    Rajendrasozhan, Saravanan
    Hetta, Mona H.
    Aly, Shaza H.
    Ali, Mohamed A.
    MOLECULES, 2022, 27 (06):
  • [22] The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro
    Hu, K
    Yao, XS
    CANCER INVESTIGATION, 2003, 21 (03) : 389 - 393
  • [23] In vitro and in silico study of eggplant extract on human cancer cell lines
    Sharma, Himanshu
    Chawla, Neena
    Dhatt, Ajmer Singh
    Deka, Dipak
    Singh, Sarabjot
    NATURAL PRODUCT RESEARCH, 2024,
  • [24] STUDY OF THE MECHANISM OF IN VITRO CYTOTOXICITY OF ANTIDEPRESSANT DRUGS ON HUMAN CANCER CELL LINES
    Quintana, O.
    Raczka, E.
    Quintana, A.
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2008, 30 : 123 - 123
  • [25] IN VITRO CYTOTOXICITY OF MADHUCA INDICA AGAINST DIFFERENT HUMAN CANCER CELL LINES
    Shaban, Asima
    Verma, Satish K.
    Nautiyal, Rajesh
    Singh, Santosh Kumar
    Purohit, Reena
    Chimata, Madhvi Lata
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2012, 3 (05): : 1385 - 1387
  • [26] Ziziphus spina-christi extract-stabilized novel silver nanoparticle synthesis for combating Fusarium oxysporum-causing pepper wilt disease: in vitro and in vivo studies
    Amer M. Abdelaziz
    Mohammed A. Elshaer
    Mohamed A. Abd-Elraheem
    Omar M Omar M Ali
    Muhammad I. Haggag
    Gharieb S. El-Sayyad
    Mohamed S. Attia
    Archives of Microbiology, 2023, 205
  • [27] Cytotoxicity screening of Melastoma malabathricum extracts on human breast cancer cell lines in vitro
    Nurfariza Ahmad Roslen
    Nur Aizura Mat Alewi
    Hadji Ahamada
    Mohammad Syaiful Bahari Abdull Rasad
    Asian Pacific Journal of Tropical Biomedicine, 2014, (07) : 545 - 548
  • [28] In vitro cytotoxicity of biosynthesized titanium dioxide nanoparticles in human prostate cancer cell lines
    He, Feiping
    Yu, Weixing
    Fan, Xiaosong
    Jin, Baiye
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (12) : 2793 - 2799
  • [29] Sesquiterpenes from Syneilesis palmata and their cytotoxicity against human cancer cell lines in vitro
    Lee, KH
    Choi, SU
    Lee, KR
    ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (03) : 280 - 284
  • [30] In vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines
    Paula M.Kustiawan
    Songchan Puthong
    Enos T.Arung
    Chanpen Chanchao
    Asian Pacific Journal of Tropical Biomedicine, 2014, (07) : 549 - 556
12345