In vitro cytotoxicity analysis of Zizyphus spina-christi stem bark extract on human cancer cell lines

被引：2
|
作者：
Rajendrasozhan, Saravanan [1 ]
Ads, Essam N. [2 ]
Abouzied, Amr S. [3 ,4 ]
Humaidi, Jamal R. [1 ]
机构：
[1] Univ Hail, Coll Sci, Dept Chem, Hail 55476, Saudi Arabia
[2] Zagazig Univ, Fac Sci, Mansoura 35522, Egypt
[3] Univ Hail, Coll Pharm, Dept Pharmaceut Chem, Hail 55476, Saudi Arabia
[4] Natl Org Drug Control & Res, Dept Pharmaceut Chem, Giza 35521, Egypt
来源：
BIOINFORMATION | 2021年 / 17卷 / 05期
关键词：
Anticancer; cytotoxic; phytochemicals; natural remedies; Zizyphus spina-christi; ACID;
D O I：
10.6026/97320630017583
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Zizyphus spina-christi (Rhamnaceae family) is an edible plant used in folk medicine. Therefore, it is of interest to report the cytotoxic effects of Z. spina-christi bark crude extract on human cell lines. Crude ethanol extract of Z. spina-christi bark was fractionated with increasing polarity (diethyl ether, chloroform, ethyl acetate and butanol fractions). The fractions were examined for their cytotoxicity against human colon cancer (HCT-116 and CACO-2), cervical cancer (HeLa and HEp-2), lung carcinoma (A-549), hepatocellular carcinoma (HepG-2), breast cancer (MCF-7) and prostate cancer (PC-3) cell lines using viability assay. Diethyl ether fraction of Z. spina-christi showed the highest cytotoxic effects among the four extracts of Z. spina-christi. The IC50 of diethyl ether fraction was 7.14, 11.2, 11.6, 15.4, 39.8, 42.2, 84.2 and 153.8 mu g/ml on HepG-2, A-549, CACO-2, HCT-116, MCF-7, PC-3, HeLa, and HEp-2 cell lines, respectively. Data shows that the diethyl ether fraction of Z. spina-christi showed effective cytotoxic effects in colon, lung and hepatocellular cancer cell lines.
引用
收藏
页码：583 / 592
页数：10
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