Sarcoidosis associated with interferon-α therapy for chronic hepatitis C

被引：0
作者：
Papaioannides, D
Fotinou, M
Korantzopoulos, P
Latsi, P
Sinapidis, D
Akritidis, N
Orphanidou, D
机构：
[1] Arta Gen Hosp, Dept Med, Arta, Greece
[2] Sotiria Hosp, Dept Pathol, Athens, Greece
[3] Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, Athens, Greece
来源：
MEDICAL SCIENCE MONITOR | 2004年 / 10卷 / 01期
关键词：
IFN-alpha; interferon-alpha; SACE-serum angiotensin converting enzyme;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recombinant interferon-alpha (IFN-alpha) is widely used for the treatment of chronic hepatitis C. Pulmonary side effects of IFN-alpha therapy seem to be rare. So far, only a few cases of sarcoidosis in association with IFN-a treatment of chronic hepatitis C have been reported. A 52-year-old woman with chronic hepatitis C developed sarcoidosis during treatment with IFN-alpha. Diagnosis of sarcoidosis was based on chest imaging studies, the increased serum angiotensin converting enzyme levels, and the histology of a biopsied cervical lymph node. Spontaneous remission was observed following IFN-alpha withdrawal. Use of recombinant IFN-alpha in patients with chronic hepatitis C may trigger or contribute to the development of sarcoidosis in susceptible individuals. Patients should be monitored during and following IFN-alpha therapy for the occurrence of manifestations suggesting sarcoidosis.
引用
收藏
页码：CS5 / CS7
页数：3
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