Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection

被引：38

作者：

Mohamed, Mohamed F. ^{[1
]}

Seleem, Mohamed N. ^{[1
]}

机构：

[1] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2014年 / 8卷

关键词：

antimicrobial peptides; MRSA; lysostaphin; skin infection; mice; IN-VIVO; LYSOSTAPHIN; INFLAMMATION; WOUNDS; ALPHA;

D O I：

10.2147/DDDT.S72129

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.

引用

页码：1979 / 1983

页数：5

共 50 条

[41] Understanding the antimicrobial activity of selected disinfectants against methicillin-resistant Staphylococcus aureus (MRSA)
Aboualizadeh, Ebrahim
Bumah, Violet V.
Masson-Meyers, Daniela S.
Eells, Janis T.
Hirschmugl, Carol J.
Enwemeka, Chukuka S.
PLOS ONE, 2017, 12 (10):
[42] Describing Antimicrobial Use among Inpatients Infected with Methicillin-Resistant Staphylococcus aureus (MRSA)
Caffrey, Aisling R.
Quilliam, Brian J.
LaPlante, Kerry L.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2010, 19 : S19 - S19
[43] Optimization of the Antimicrobial Effect of Blue Light on Methicillin-Resistant Staphylococcus aureus (MRSA) In Vitro
Bumah, Violet V.
Masson-Meyers, Daniela S.
Cashin, Susan
Enwemeka, Chukuka S.
LASERS IN SURGERY AND MEDICINE, 2015, 47 (03) : 266 - 272
[44] Community-Acquired Methicillin-Resistant Staphylococcus aureus Skin Infection
Constantinescu, Monica
English, Joseph C., III
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, 2011, 24 (04) : 231 - 232
[45] Targeting Methicillin-Resistant Staphylococcus aureus with Short Salt-Resistant Synthetic Peptides
Mohamed, Mohamed F.
Hamed, Maha I.
Panitch, Alyssa
Seleem, Mohamed N.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) : 4113 - 4122
[46] Auranofin Rapidly Eradicates Methicillin-resistant Staphylococcus aureus (MRSA) in an Infected Pressure Ulcer Mouse Model
Haroon Mohammad
Nader S. Abutaleb
Mohamed N. Seleem
Scientific Reports, 10
[47] Does a Positive Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screen Predict the Risk for MRSA Skin and Soft Tissue Infection?
Hitchcock, Allison M.
Seabury, Robert W.
Kufel, Wesley D.
Farooqi, Sara
Steele, Jeffrey M.
Darko, William
Miller, Christopher D.
Feldman, Elizabeth A.
ANNALS OF PHARMACOTHERAPY, 2023, 57 (06) : 669 - 676
[48] Auranofin Rapidly Eradicates Methicillin-resistant Staphylococcus aureus (MRSA) in an Infected Pressure Ulcer Mouse Model
Mohammad, Haroon
Abutaleb, Nader S.
Seleem, Mohamed N.
SCIENTIFIC REPORTS, 2020, 10 (01)
[49] Methicillin-resistant Staphylococcus aureus (MRSA) on the skin of long-term hospitalised horses
Van den Eede, A.
Hermans, K.
Van den Abeele, A.
Flore, K.
Dewulf, J.
Vanderhaeghen, W.
Crombe, F.
Butaye, P.
Gasthuys, F.
Haesebrouck, F.
Martens, A.
VETERINARY JOURNAL, 2012, 193 (02): : 408 - 411
[50] Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries
Katakura, T
Yoshida, T
Kobayashi, M
Herndon, DN
Suzuki, F
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 142 (03): : 419 - 425

← 1 2 3 4 5 →