Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection

被引：38
|
作者：
Mohamed, Mohamed F. [1 ]
Seleem, Mohamed N. [1 ]
机构：
[1] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2014年 / 8卷
关键词：
antimicrobial peptides; MRSA; lysostaphin; skin infection; mice; IN-VIVO; LYSOSTAPHIN; INFLAMMATION; WOUNDS; ALPHA;
D O I：
10.2147/DDDT.S72129
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureus USA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.
引用
收藏
页码：1979 / 1983
页数：5
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