Inflammatory proteinase slips into tumor cells

被引：4

作者：

Fingleton, Barbara ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37235 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 02期

关键词：

LUNG-CANCER; DISEASE;

D O I：

10.1038/nm0210-161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory cells can promote tumor cell proliferation, but the range of mechanisms has not been fully explored. A proteinase produced by neutrophils is now shown to enter tumor cells and promote their proliferation (pages 219–223).

引用

页码：161 / 163

页数：4

共 12 条

[1] Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma [J].

Boivin, Wendy Anne ;

Cooper, Dawn Michelle ;

Hiebert, Paul Ryan ;

Granville, David James .

LABORATORY INVESTIGATION, 2009, 89 (11) :1195-1220

[2] Annual Report to the Nation on the Status of Cancer, 1975-2006, Featuring Colorectal Cancer Trends and Impact of Interventions (Risk Factors, Screening, and Treatment) to Reduce Future Rates [J].

Edwards, Brenda K. ;

Ward, Elizabeth ;

Kohler, Betsy A. ;

Eheman, Christie ;

Zauber, Ann G. ;

Anderson, Robert N. ;

Jemal, Ahmedin ;

Schymura, Maria J. ;

Lansdorp-Vogelaar, Iris ;

Seeff, Laura C. ;

van Ballegooijen, Marjolein ;

Goede, S. Luuk ;

Ries, Lynn A. G. .

CANCER, 2010, 116 (03) :544-573

[3] Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].

Fridlender, Zvi G. ;

Sun, Jing ;

Kim, Samuel ;

Kapoor, Veena ;

Cheng, Guanjun ;

Ling, Leona ;

Worthen, G. Scott ;

Albelda, Steven M. .

CANCER CELL, 2009, 16 (03) :183-194

[4] Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth [J].

Houghton, A. McGarry ;

Rzymkiewicz, Danuta M. ;

Ji, Hongbin ;

Gregory, Alyssa D. ;

Egea, Eduardo E. ;

Metz, Heather E. ;

Stolz, Donna B. ;

Land, Stephanie R. ;

Marconcini, Luiz A. ;

Kliment, Corrine R. ;

Jenkins, Kimberly M. ;

Beaulieu, Keith A. ;

Mouded, Majd ;

Frank, Stuart J. ;

Wong, Kwok K. ;

Shapiro, Steven D. .

NATURE MEDICINE, 2010, 16 (02) :219-U127

[5] Receptor-mediated uptake of pepsin by laryngeal epithelial cells [J].

Johnston, Nikki ;

Wells, Clive W. ;

Blumin, Joel H. ;

Toohill, Robert J. ;

Merati, Albert L. .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2007, 116 (12) :934-938

[6]

KAWAHARA Y, ESOPHAGUS

[7] Chronic Obstructive Pulmonary Disease and Altered Risk of Lung Cancer in a Population-Based Case-Control Study [J].

Koshiol, Jill ;

Rotunno, Melissa ;

Consonni, Dario ;

Pesatori, Angela Cecilia ;

De Matteis, Sara ;

Goldstein, Alisa M. ;

Chaturvedi, Anil K. ;

Wacholder, Sholom ;

Landi, Maria Teresa ;

Lubin, Jay H. ;

Caporaso, Neil E. .

PLOS ONE, 2009, 4 (10)

[8] Distinct role of macrophages in different tumor microenvironments [J].

Lewis, CE ;

Pollard, JW .

CANCER RESEARCH, 2006, 66 (02) :605-612

[9] The dual role of neutrophil elastase in lung destruction and repair [J].

Lungarella, Giuseppe ;

Cavarra, Eleonora ;

Lucattelli, Monica ;

Martorana, Piero A. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (6-7) :1287-1296

[10] Intracellular targets of matrix metalloproteinase-2 in cardiac disease: Rationale and therapeutic approaches [J].

Schulz, Richard .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2007, 47 :211-242

← 1 2 →