Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α

被引:49
|
作者
Clark, Amanda J. [1 ,2 ]
Parikh, Samir M. [2 ,3 ,4 ]
机构
[1] Boston Childrens Hosp, Div Nephrol, Boston, MA USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] Beth Israel Deaconess Med Ctr, Div Nephrol, Boston, MA USA
[4] Beth Israel Deaconess Med Ctr, Ctr Vasc Biol Res, Boston, MA USA
基金
美国国家卫生研究院;
关键词
acute kidney injury; diabetic nephropathy; fibrosis; mitochondria; proteinuria;
D O I
10.1016/j.kint.2020.09.037
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those demands and maintain renal fitness. Decades of studies have linked poor mitochondrial health to kidney disease. Key regulators of mitochondrial health-adenosine monophosphate kinase, sirtuins, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha-have all been shown to play significant roles in renal resilience against disease. This review will summarize the latest research into the activities of those regulators and evaluate the roles and therapeutic potential of targeting those regulators in acute kidney injury, glomerular kidney disease, and renal fibrosis.
引用
收藏
页码:828 / 840
页数:13
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