B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses

被引：22
作者：
Ireland, Sara J. [1 ]
Guzman, Alyssa A. [1 ]
Frohman, Elliot M. [1 ]
Monson, Nancy L. [1 ,2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, 6000 Harry Hines Blvd, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Immunol, 6000 Harry Hines Blvd, Dallas, TX 75390 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 291卷
关键词：
Multiple sclerosis; B cells; Th17; cells; MEMORY T-LYMPHOCYTES; EXTRACELLULAR DOMAIN; DEPLETION; DISEASE; NAIVE; ACTIVATION; INDUCTION; RITUXIMAB; THERAPY; SUBSETS;
D O I：
10.1016/j.jneuroim.2015.11.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
B cells are highly potent antigen presenting cells of their cognate antigens. However, it remains unknown whether B cells can orchestrate Th17-mediated responses against neuro-antigens. We report that MS patients and healthy donors had a similar frequency of antigen-specific Th1 and Th17 cells, and distribution of T effector and T central memory cells. Notwithstanding these similarities, the application of an in vitro assay demonstrated that the B cells derived from a subset of MS patients exhibited the capability of coordinating Th17 responses directed toward neuro-antigens. These observations underscore the B cell's contribution to the putative underpinnings of multiple sclerosis. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：46 / 53
页数：8
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