Modeling membrane shaping by proteins: Focus on EHD2 and N-BAR domains

被引：47

作者：

Campelo, Felix ^{[1
,2
]}

Fabrikant, Gur ^{[1
]}

McMahon, Harvey T. ^{[3
]}

Kozlov, Michael M. ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

[2] CRG, Dept Cell & Dev Biol, Barcelona, Spain

[3] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

基金：

以色列科学基金会;

关键词：

Membrane curvature; Membrane shaping; Membrane fusion; Membrane fission; EHD2; N-BAR; MOLECULAR-DYNAMICS SIMULATIONS; LATERAL PRESSURE PROFILE; COATED VESICLE FORMATION; CELL-FUSION; MITOCHONDRIAL MORPHOLOGY; TRANSPORT CARRIERS; STRUCTURAL BASIS; PLASMA-MEMBRANE; COPII VESICLE; SPONTANEOUS CURVATURE;

D O I：

10.1016/j.febslet.2009.10.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular membranes are highly dynamic, undergoing both persistent and dynamic shape changes driven by specialized proteins. The observed membrane shaping can be simple deformations of existing shapes or membrane remodeling involving fission or fusion. Here we describe several mechanistic principles by which membrane shaping proteins act. We especially consider models for membrane bending and fission by EHD2 proteins and membrane bending by N-BAR domains. There are major challenges ahead to understand the general principles by which diverse membrane bending proteins act and to understand how some proteins appear to span multiple modes of action from driving curvature to inducing membrane remodeling. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1830 / 1839

页数：10

共 120 条

[1]

Alper Scott, 2008, V475, P53, DOI 10.1007/978-1-59745-250-2_4

[2] Membrane deformation by protein coats [J].

Antonny, Bruno .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (04) :386-394

[3] The formation of TGN-to-plasma-membrane transport carriers [J].

Bard, Frederic ;

Malhotra, Vivek .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :439-455

[4] GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission [J].

Bashkirov, Pavel V. ;

Akimov, Sergey A. ;

Evseev, Alexey I. ;

Schmid, Sandra L. ;

Zimmerberg, Joshua ;

Frolov, Vadim A. .

CELL, 2008, 135 (07) :1276-1286

[5]

BECK R, 2009, FEBS LETT

[6]

BENSHAUL A, 1995, STRUCTURE DYNAMICS M, P359

[7] A structural view of the COPII vesicle coat [J].

Bickford, LC ;

Mossessova, E ;

Goldberg, J .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (02) :147-153

[8] Factors influencing local membrane curvature induction by N-BAR domains as revealed by molecular dynamics simulations [J].

Blood, Philip D. ;

Swenson, Richard D. ;

Voth, Gregory A. .

BIOPHYSICAL JOURNAL, 2008, 95 (04) :1866-1876

[9] Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations [J].

Blood, Philip D. ;

Voth, Gregory A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (41) :15068-15072

[10] Opinion - Coat proteins: shaping membrane transport [J].

Bonifacino, JS ;

Lippincott-Schwartz, J .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (05) :409-414

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