Immunolocalization of apolipoprotein D, androgen receptor and prostate specific antigen in early stage prostate cancers

被引：21
作者：
Zhang, SXD
Bentel, JM
Ricciardelli, C
Horsfall, DJ
Haagensen, DE
Marshall, VR
Tilley, WD [1 ]
机构：
[1] Flinders Univ S Australia, Flinders Med Ctr, Sch Med, Dept Surg, Bedford Pk, SA 5042, Australia
[2] Methodist Hosp, Dept Surg, Sacramento, CA USA
来源：
JOURNAL OF UROLOGY | 1998年 / 159卷 / 02期
基金：
英国医学研究理事会;
关键词：
prostatic neoplasms; immunohistochemistry; apolipoproteins; androgen receptor; prostate specific antigen;
D O I：
10.1016/S0022-5347(01)63981-8
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose: To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers. Materials and Methods: Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis. Results: Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate. Conclusions: Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.
引用
收藏
页码：548 / 554
页数：7
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