PURPOSE. To investigate the association between the size and shape of the foveal avascular zone and retinal thickness in healthy subjects. METHODS. In vivo imaging of the foveal microvasculature was performed on 32 subjects by using an adaptive optics scanning laser ophthalmoscope (AOSLO). Motion contrast maps of the AOSLO images were used to generate a montage revealing the foveal capillary network. Foveal avascular zone (FAZ) diameters along the horizontal (FAZ(H)) and vertical (FAZ(V)) meridians were measured on the montages. An asymmetry index (AI) of the FAZ was then computed as the ratio of the FAZ(H) to FAZ(V). Retinal thickness was investigated by using spectral-domain optical coherence tomography (SDOCT). Inner retinal layer (INLFAZ) thickness and outer nuclear layer (ONLFAZ) thickness were measured at the edges of the FAZ on the horizontal and vertical SDOCT scans on the same eye. RESULTS. The foveal capillary network was readily visualized in all subjects. As expected there was individual variation in the size and shape of the FAZ. Along the horizontal and vertical meridians, the mean +/- SD (mu m) of the FAZ diameter was 607 +/- 217 and 574 +/- 155, respectively. The INLFAZ thickness was 68 +/- 9 and 66 +/- 9, and the ONLFAZ thickness was 103 +/- 13 and 105 +/- 11, respectively. The mean +/- SD of the AI was 1.03 +/- 0.27. The difference between FAZ(H) and FAZ(V) decreases with increasing FAZ area (P = 0.004). Mean ONLFAZ was negatively correlated with FAZ effective diameter (P < 0.0001). No significant correlation was found between mean INLFAZ and FAZ effective diameter (P = 0.16). CONCLUSIONS. Despite large individual variations in size and shape of the FAZ, the INLFAZ has a relatively constant thickness at the margins of the FAZ, suggesting the presence of retinal capillaries is needed to sustain an INLFAZ thickness greater than 60 mu m. A smaller FAZ area is associated with a vertically elongated FAZ.
机构:
Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Samara, Wasim A.
Say, Emil A. T.
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Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Say, Emil A. T.
Khoo, Chloe T. L.
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h-index: 0
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Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Khoo, Chloe T. L.
Higgins, Timothy P.
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h-index: 0
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Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Higgins, Timothy P.
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Magrath, George
Ferenczy, Sandor
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Ferenczy, Sandor
Shields, Carol L.
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Thomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USAThomas Jefferson Univ, Wills Eye Hosp, Ocular Oncol Serv, Philadelphia, PA 19107 USA
Shields, Carol L.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,
2015,
35
(11):
: 2188
-
2195
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Li, Fei
Lin, Fengbin
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Lin, Fengbin
Gao, Kai
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Gao, Kai
Cheng, Weijing
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Cheng, Weijing
Song, Yunhe
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机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Song, Yunhe
Liu, Yuhong
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Liu, Yuhong
Wang, Yu Meng
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h-index: 0
机构:
Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Wang, Yu Meng
Lam, Alexander
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h-index: 0
机构:
Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Lam, Alexander
Tham, Clement C.
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h-index: 0
机构:
Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Tham, Clement C.
Cheung, Carol
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Cheung, Carol
Zhang, Xiulan
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h-index: 0
机构:
Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R ChinaSun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
Zhang, Xiulan
Zangwill, Linda M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Viterbi Family Dept Ophthalmol, Hamilton Glaucoma Ctr, Shiley Eye Inst, La Jolla, CA 92093 USASun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China
机构:
Vitreous Retina Macula Consultants New York, New York, NY 10022 USA
Manhattan Eye Ear & Throat Hosp, Luesther T Mertz Retinal Res Ctr, New York, NY 10021 USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Balaratnasingam, Chandrakumar
Chae, Bora
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Ophthalmol, New York, NY USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Chae, Bora
Remmer, Meredith H.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Ophthalmol, New York, NY USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Remmer, Meredith H.
Gomez, Erasmo
论文数: 0引用数: 0
h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY 10022 USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Gomez, Erasmo
Suzuki, Mihoko
论文数: 0引用数: 0
h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY 10022 USA
Manhattan Eye Ear & Throat Hosp, Luesther T Mertz Retinal Res Ctr, New York, NY 10021 USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Suzuki, Mihoko
Engelbert, Michael
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h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY 10022 USA
Manhattan Eye Ear & Throat Hosp, Luesther T Mertz Retinal Res Ctr, New York, NY 10021 USA
NYU, Sch Med, Dept Ophthalmol, New York, NY USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
Engelbert, Michael
Spaide, Richard F.
论文数: 0引用数: 0
h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY 10022 USA
Manhattan Eye Ear & Throat Hosp, Luesther T Mertz Retinal Res Ctr, New York, NY 10021 USAVitreous Retina Macula Consultants New York, New York, NY 10022 USA
机构:
Karolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, SwedenKarolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, Sweden
de Salles, Manuel Casselholm
Kvanta, Anders
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机构:
Karolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, SwedenKarolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, Sweden
Kvanta, Anders
Amren, Urban
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机构:
Karolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, SwedenKarolinska Inst, St Erik Eye Hosp, Polhemsgatan 50, S-11282 Stockholm, Sweden
机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Univ Santiago de Compostela, Dept Surg, Santiago De Compostela, Spain
Univ Santiago de Compostela, CIMUS, Santiago De Compostela, Spain
IDIS, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Gomez-Ulla, Francisco
Cutrin, Paula
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机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Cutrin, Paula
Santos, Paz
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机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Santos, Paz
Fernandez, Maribel
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h-index: 0
机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Univ Santiago de Compostela, Dept Surg, Santiago De Compostela, Spain
Univ Santiago de Compostela, CIMUS, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Fernandez, Maribel
Abraldes, Maximino
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h-index: 0
机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Univ Santiago de Compostela, Dept Surg, Santiago De Compostela, Spain
Univ Santiago de Compostela, CIMUS, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain
Abraldes, Maximino
Manuel Abalo-Lojo, Jose
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h-index: 0
机构:
CHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, SpainCHU Santiago De Compostela, Serv Ophthalmol, Santiago De Compostela, Spain