Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout

被引：80

作者：

Bursill, David ^{[1
]}

Taylor, William J. ^{[2
,3
]}

Terkeltaub, Robert ^{[4
]}

Abhishek, Abhishek ^{[5
]}

So, Alexander K. ^{[6
]}

Vargas-Santos, Ana Beatriz ^{[7
]}

Gaffo, Angelo Lino ^{[8
]}

Rosenthal, Ann ^{[9
,10
]}

Tausche, Anne-Kathrin ^{[11
]}

Reginato, Anthony ^{[12
]}

Manger, Bernhard ^{[13
]}

Scire, Carlo ^{[14
,15
]}

Pineda, Carlos ^{[16
]}

van Durme, Caroline ^{[17
]}

Lin, Ching-Tsai ^{[18
]}

Yin, Congcong ^{[19
]}

Albert, Daniel Arthur ^{[20
]}

Biernat-Kaluza, Edyta ^{[21
]}

Roddy, Edward ^{[22
]}

Pascual, Eliseo ^{[23
,24
]}

Becce, Fabio ^{[25
]}

Perez-Ruiz, Fernando ^{[26
,27
,28
]}

Sivera, Francisca ^{[29
]}

Liote, Frederic ^{[30
,31
,32
]}

Schett, Georg ^{[33
,34
]}

Nuki, George ^{[35
]}

Filippou, Georgios ^{[36
]}

McCarthy, Geraldine ^{[37
,38
]}

Castelar Pinheiro, Geraldo da Rocha ^{[39
]}

Ea, Hang-Korng ^{[40
]}

Tupinamba, Helena De Almeida ^{[41
]}

Yamanaka, Hisashi ^{[42
,43
]}

Choi, Hyon K. ^{[44
,45
]}

Mackay, James ^{[46
]}

ODell, James R. ^{[47
]}

Vazquez Mellado, Janitzia ^{[48
,49
]}

Singh, Jasvinder A. ^{[50
,51
,52
]}

Fitzgerald, John D. ^{[53
]}

Jacobsson, Lennart T. H. ^{[54
]}

Joosten, Leo ^{[55
]}

Harrold, Leslie R. ^{[56
,57
]}

Stamp, Lisa ^{[58
]}

Andres, Mariano ^{[59
,60
]}

Gutierrez, Marwin ^{[61
,71
]}

Kuwabara, Masanari ^{[62
,63
,73
,74
,75
]}

Dehlin, Mats ^{[64
]}

Janssen, Matthijs ^{[65
]}

Doherty, Michael ^{[5
]}

Hershfield, Michael S. ^{[66
]}

Pillinger, Michael ^{[67
]}

机构：

[1] Univ Adelaide, Dept Hlth & Med Sci, Adelaide, SA, Australia

[2] Univ Otago, Dept Med, Wellington, New Zealand

[3] Hutt Valley Dist Hlth Board, Wellington Reg Rheumatol Unit, Lower Hutt, New Zealand

[4] UCSD VA Med Ctr, Dept Rheumatol, San Diego, CA USA

[5] Univ Nottingham, Dept Acad Rheumatol, Nottingham, England

[6] Serv RMR, Dept Musculoskeletal Med, Lausanne, Switzerland

[7] Univ Estado Rio De Janeiro, Rheumatol Unit, Dept Internal Med, Rio De Janeiro, Brazil

[8] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[9] Med Coll Wisconsin, Div Rheumatol, Milwaukee, WI 53226 USA

[10] Clement J Zablocki VA Med Ctr, Translat Res Unit, Milwaukee, WI USA

[11] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Rheumatol, Dresden, Germany

[12] Brown Univ, Warren Alpert Sch Med, Div Rheumatol, Providence, RI 02912 USA

[13] Univ Erlangen Nurnberg, Rheumatol & Immunol, Erlangen, Germany

[14] Univ Ferrara, Dept Med Sci, Sect Rheumatol, Ferrara, Italy

[15] Italian Soc Rheumatol, Epidemiol Unit, Milan, Italy

[16] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Rheumatol, Mexico City, DF, Mexico

[17] Maastricht Univ, Med Ctr, Div Rheumatol, Dept Internal Med, Maastricht, Netherlands

[18] Taichung Vet Gen Hosp, Div Allergy Immunol & Rheumatol, Taichung, Taiwan

[19] Henry Ford Hlth Syst, Dept Immunol & Dermatol, Detroit, MI USA

[20] Dartmouth Hitchcock Med Ctr, Dept Rheumatol, Hanover, NH USA

[21] ORLIK, Nutr & Lifestyle Med Ctr, Outpatient Rheumatol Clin, Warsaw, Poland

[22] Keele Univ, Res Inst Primary Care & Hlth Sci, Keele, Staffs, England

[23] Hosp Gen Univ Alicante, Dept Rheumatol, Alicante, Spain

[24] Univ Miguel Hernandez, Dept Clin Med, Alicante, Spain

[25] Univ Lausanne, Dept Diagnost & Intervent Radiol, Lausanne, Switzerland

[26] Cruces Univ Hosp, Rheumatol Div, Baracaldo, Spain

[27] Univ Basque Country, Dept Med, Biscay, Spain

[28] Biocruces Hlth Res Inst, Invest Grp Arthrit, Baracaldo, Spain

[29] Hosp Gen Univ Elda, Dept Rheumatol, Elda, Spain

[30] Hop Lariboisiere, Assistance Publ Hop Paris, Dept Rheumatol, Paris, France

[31] INSERM, UMR 1132, Dept Rheumatol, Paris, France

[32] Univ Paris Diderot, Paris, France

[33] Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Erlangen, Germany

[34] Univ Klinikum Erlangen, Erlangen, Germany

[35] Univ Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland

[36] Univ Ferrara, Dept Med Sci, Sect Rheumatol, Ferrara, Italy

[37] Mater Misericordiae Univ Hosp, Dept Rheumatol, Dublin, Ireland

[38] Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland

[39] Univ Estado Rio De Janeiro, Rheumatol Unit, Dept Internal Med, Rio De Janeiro, Brazil

[40] Hop Lariboisiere, Dept Rheumatol, Paris, France

[41] Univ Estado Rio De Janeiro, Rheumatol, Rio De Janeiro, Brazil

[42] Tokyo Womens Med Univ Hosp, Inst Rheumatol, Tokyo, Japan

[43] Tokyo Womens Med Univ, Sch Med, Tokyo, Japan

[44] Harvard Med Sch, Sect Rheumatol & Clin Epidemiol, Boston, MA 02115 USA

[45] Massachusetts Gen Hosp, Boston, MA 02114 USA

[46] Aristea Therapeut, San Diego, CA USA

[47] Univ Nebraska Med Ctr, Div Rheumatol, Omaha, NE USA

[48] Hosp Gen Mexico City, Dept Rheumatol, Mexico City, DF, Mexico

[49] Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico

[50] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2019年 / 78卷 / 11期

关键词：

EVIDENCE-BASED RECOMMENDATIONS; MANAGEMENT;

D O I：

10.1136/annrheumdis-2019-215933

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective There is a lack of standardisation in the terminology used to describe gout. The aim of this project was to develop a consensus statement describing the recommended nomenclature for disease states of gout. Methods A content analysis of gout-related articles from rheumatology and general internal medicine journals published over a 5-year period identified potential disease states and the labels commonly assigned to them. Based on these findings, experts in gout were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach agreement on disease state labels and definitions. Results The content analysis identified 13 unique disease states and a total of 63 unique labels. The Delphi exercise (n=76 respondents) and face-to-face meeting (n=35 attendees) established consensus agreement for eight disease state labels and definitions. The agreed labels were as follows: 'asymptomatic hyperuricaemia', 'asymptomatic monosodium urate crystal deposition', 'asymptomatic hyperuricaemia with monosodium urate crystal deposition', 'gout', 'tophaceous gout', 'erosive gout', 'first gout flare' and 'recurrent gout flares'. There was consensus agreement that the label 'gout' should be restricted to current or prior clinically evident disease caused by monosodium urate crystal deposition (gout flare, chronic gouty arthritis or subcutaneous tophus). Conclusion Consensus agreement has been established for the labels and definitions of eight gout disease states, including 'gout' itself. The Gout, Hyperuricaemia and Crystal-Associated Disease Network recommends the use of these labels when describing disease states of gout in research and clinical practice.

引用

页码：1592 / 1600

页数：9

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