Design and synthesis of a new selective fluorescent chemical sensor for Cu2+ based on a Pyrrole moiety and a Fluorescein conjugate

被引：45

作者：

Bao, Xiaofeng ^{[1
]}

Cao, Qiansheng ^{[1
]}

Wu, Xiaolei ^{[1
]}

Shu, Hai ^{[1
]}

Zhou, Baojing ^{[3
]}

Geng, Yougliang ^{[3
]}

Zhu, Jing ^{[2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Dept Biochem Engn, 200 Xiaolinwei, Nanjing 210094, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Pharm, 138 Xianlin Dadao, Nanjing 210023, Jiangsu, Peoples R China

[3] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 08期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Fluorescein; Pyrrole; Chemical sensor; Cu2+; RHODAMINE-B; PROBE; CHEMOSENSOR; NANOPARTICLES; RECOGNITION; IONS;

D O I：

10.1016/j.tetlet.2016.01.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new fluorescein derivative, namely, (E)-2-(((1H-pyrrol-2-yl)methylene)amino)-3',6'-dihydroxyspiro [isoindoline-1,9'-xanthenl-3-one (FLPY), was designed, synthesized, and structurally characterized to develop a chemosensor. The interactions of FLPY with different metal ions have been studied over UV-vis absorption spectra and fluorescent spectra. The results show that FLPY exhibits high sensitivity and selectivity toward Cu2+ among many other metal cations in a DMSO/HEPES (3:1, v/v, 1 mM, pH 7.2) solution. The binding association constant (Ka) of FLPY for Cu based on a 1:1 stoichiometry was estimated to be 1.29 x 10(4) M-1 in the solution. The detection limit of Cu2+ by FLPY was further determined to be 0.296 M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：942 / 948

页数：7

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