Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase

被引：98

作者：

Liang, Gaoyang ^{[1
]}

Klose, Robert J. ^{[1
]}

Gardner, Kathryn E. ^{[1
]}

Zhang, Yi ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Howard Hughes Med Inst, Chapel Hill, NC 27599 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 03期

关键词：

D O I：

10.1038/nsmb1204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.

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页码：243 / 245

页数：3

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