Successful Treatment of Severe Aspergillosis with Isavuconazole Therapy after Allogeneic Stem Cell Transplantation

被引：1

作者：

Oarbeascoa, Gillen ^{[1
,2
]}

Dorado, Nieves ^{[1
,2
]}

Bailen, Rebeca ^{[1
,2
]}

Serrano, David ^{[1
,2
]}

Balsalobre, Pascual ^{[1
,2
]}

Pradillo, Virginia ^{[1
]}

Guinea, Jesus ^{[2
,3
,4
,5
]}

Padilla, Belen ^{[2
,3
]}

Sancho, Milagros ^{[2
,6
]}

Machado, Marina ^{[2
,3
]}

Buno, Ismael ^{[1
,2
,7
]}

Anguita, Javier ^{[1
,2
]}

Luis Diez-Martin, Jose ^{[1
,2
,4
]}

Kwon, Mi ^{[1
,2
]}

机构：

[1] Hosp Gen Univ Gregorio Maranon, Dept Hematol, Dr Esquerdo 46 St, ES-28007 Madrid, Spain

[2] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain

[3] Hosp Gen Univ Gregorio Maranon, Clin Microbiol & Infect Dis HIV Dept, Madrid, Spain

[4] Univ Complutense Madrid, Madrid, Spain

[5] CIBER Enfermedades Resp CIBERES CB06 06 0058, Madrid, Spain

[6] Hosp Gen Univ Gregorio Maranon, Intens Care Unit, Madrid, Spain

[7] Hosp Gen Univ Gregorio Maranon, Genom Unit, Madrid, Spain

来源：

CHEMOTHERAPY | 2019年 / 64卷 / 02期

关键词：

Antifungal agents; Antifungals; Aspergillosis; Isavuconazole; Stem cell transplantation; Interaction; INVASIVE FUNGAL-INFECTIONS; RISK-FACTORS; EPIDEMIOLOGY; MANAGEMENT; RECIPIENTS; DISEASES;

D O I：

10.1159/000502279

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Invasive fungal infections are one of the main infectious complications in allogeneic stem cell transplantation (SCT). Triazoles (voriconazole, posaconazole) are the main prophylactic and therapeutic options for the treatment of invasive aspergillosis. However, pharmacological interactions and hepatotoxicity limit its use. Isavuconazole (ISV) is a recently approved azole with a promising interaction and safety profile. We present a case with invasive aspergillosis in the post-allogeneic SCT setting in a critically ill patient with severe multiorgan failure due to veno-occlusive disease. The patient was treated with ISV and B amphotericin during severe kidney and liver failure and multiple immunosuppressants, without significant drug-related toxicity and with favorable outcome. The interaction and safety profile of ISV is discussed along the reported experience. ISV can be an effective salvage therapy even in complex clinical situations with multiple potential interactions.

引用

页码：57 / 61

页数：5

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