The human papillomavirus (HPV)-related cancer biology: An overview

被引：121

作者：

Araldi, Rodrigo Pinheiro ^{[1
]}

Sant'Ana, Thalita Araujo ^{[2
]}

Modolo, Diego Grando ^{[2
]}

de Melo, Thatiana Correa ^{[3
]}

Spadacci-Morena, Diva Denelle ^{[4
]}

Stocco, Rita de Cassia ^{[2
]}

Cerutti, Janete Maria ^{[1
]}

de Souza, Edislane Barreiros ^{[5
]}

机构：

[1] Sao Paulo Fed Univ UNIFESP, Genet Basis Thyroid Canc Lab, Sao Paulo, SP, Brazil

[2] Butantan Inst, Genet Lab, Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Med Sch, Haematol & Mol Biol Lab, Sao Paulo, SP, Brazil

[4] Butantan Inst, Pathophysiol Lab, Sao Paulo, SP, Brazil

[5] Sao Paulo State Univ UNESP, Fac Sci & Languages, Biotechnol Dept, Genet Lab, BR-19806900 Assis, SP, Brazil

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 106卷

基金：

巴西圣保罗研究基金会;

关键词：

Oncology; HPV; Mutation; Cancer progression; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; SQUAMOUS-CELL CARCINOMA; RISK HUMAN-PAPILLOMAVIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; STRAND BREAK REPAIR; BOVINE PAPILLOMAVIRUS; STEM-CELLS; GENOMIC INSTABILITY; PERIPHERAL-BLOOD; ESOPHAGEAL-CARCINOMA;

D O I：

10.1016/j.biopha.2018.06.149

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20-25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agentrelated cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.

引用

页码：1537 / 1556

页数：20

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