EmPHasis-10 as a measure of health-related quality of life in pulmonary arterial hypertension: data from PHAR

被引：29

作者：

Borgese, Marissa ^{[1
]}

Badesch, David ^{[2
]}

Bull, Todd ^{[2
]}

Chakinala, Murali ^{[3
]}

DeMarco, Teresa ^{[4
]}

Feldman, Jeremy ^{[5
]}

Ford, H. James ^{[6
]}

Grinnan, Dan ^{[7
]}

Klinger, James R. ^{[8
]}

Bolivar, Lena ^{[9
]}

Shlobin, Oksana A. ^{[10
]}

Frantz, Robert P. ^{[11
]}

Sager, Jeffery S. ^{[12
]}

Mathai, Stephen C. ^{[13
]}

Kawut, Steven ^{[14
]}

Leary, Peter J. ^{[15
]}

Gray, Michael P. ^{[16
]}

Popat, Rita A. ^{[1
]}

Zamanian, Roham T. ^{[17
,18
]}

机构：

[1] Stanford Univ, Dept Hlth Res & Policy, Sch Med, Stanford, CA USA

[2] Univ Colorado, Div Pulm & Crit Care Med, Denver, CO 80202 USA

[3] Washington Univ Barnes Jewish, Div Pulm & Crit Care Med, St Louis, MO USA

[4] Univ Calif San Francisco, Div Cardiol, San Francisco, CA USA

[5] Arizona Pulm Specialists, Phoenix, AZ USA

[6] Univ N Carolina, Div Pulm & Crit Care Med, Chapel Hill, NC 27515 USA

[7] Virginia Commonwealth Univ, Div Pulm & Crit Care Med, Med Ctr, Richmond, VA USA

[8] Brown Univ, Div Pulm & Crit Care Med, Providence, RI 02912 USA

[9] Patient Representat, Washington, DC USA

[10] Inova Fairfax Hosp, Falls Church, VA USA

[11] Mayo Clin Rochester, Div Cardiovasc Med, Rochester, MN USA

[12] Cottage Pulm Hypertens Ctr, Santa Barbara, CA USA

[13] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD USA

[14] Univ Penn, Div Pulm & Crit Care Med, Philadelphia, PA 19104 USA

[15] Univ Washington, Div Pulm & Crit Care Med, Seattle, WA 98195 USA

[16] Pulm Hypertens Assoc, Silver Spring, MD USA

[17] Stanford Univ, Div Pulm & Crit Care Med, Sch Med, Stanford, CA 94305 USA

[18] Stanford Univ, Vera Moulton Wall Ctr Pulm Vasc Dis, Sch Med, Stanford, CA 94305 USA

来源：

EUROPEAN RESPIRATORY JOURNAL | 2021年 / 57卷 / 02期

关键词：

GENDER-DIFFERENCES; QUESTIONNAIRE; DIFFERENCE; VALIDATION;

D O I：

10.1183/13993003.00414-2020

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: While the performance of the emPHasis-10 (e10) score has been evaluated against limited patient characteristics within the United Kingdom, there is an unmet need for exploring the performance of the e10 score among pulmonary arterial hypertension (PAH) patients in the United States. Methods: Using the Pulmonary Hypertension Association Registry, we evaluated relationships between the e10 score and demographic, functional, haemodynamic and additional clinical characteristics at baseline and over time. Furthermore, we derived a minimally important difference (MID) estimate for the e10 score. Results: We analysed data from 565 PAH (75% female) adults aged mean +/- SD 55.6 +/- 16.0 years. At baseline, the e10 score had notable correlation with factors expected to impact quality of life in the general population, including age, education level, income, smoking status and body mass index. Clinically important parameters including 6-min walk distance and B-type natriuretic peptide (BNP)/N-terminal proBNP were also significantly associated with e10 score at baseline and over time. We generated a MID estimate for the e10 score of -6.0 points (range -5.0-7.6 points). Conclusions: The e10 score was associated with demographic and clinical patient characteristics, suggesting that health-related quality of life in PAH is influenced by both social factors and indicators of disease severity. Future studies are needed to demonstrate the impact of the e10 score on clinical decision-making and its potential utility for assessing clinically important interventions.

引用

页数：13

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