Pathogenic role of HMGB1 in SARS?

被引：42
作者：
Chen, GQ
Chen, DZ
Li, JH
Czura, CJ
Tracey, KJ
Sama, AE
Wang, HC [1 ]
机构：
[1] NYU, N Shore Univ Hosp, Sch Med, Dept Emergency Med, Manhasset, NY 11030 USA
[2] N Shore LIJ Res Inst, Manhasset, NY 11030 USA
来源：
MEDICAL HYPOTHESES | 2004年 / 63卷 / 04期
关键词：
D O I：
10.1016/j.mehy.2004.01.037
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
High mobility group box 1 protein (HMGB1) is released by necrotic cells or activated macrophages/monocytes, and functions as a late mediator of Lethal systemic and Local pulmonary inflammation. Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxemia, sepsis, and acute lung injury, even when antibodies are administered after the onset of these diseases. In tight of observations that three Chinese herbal formulations recommended for treatment of severe acute respiratory syndrome (SARS) specifically inhibited the release of HMGB1 from innate immune cells, we hypothesize that HMGB1 might occupy a pathogenic rote in SARS by mediating an injurious pulmonary inflammatory response. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：691 / 695
页数：5
相关论文
共 20 条
  • [1] Cutting edge: HMG-1 as a mediator of acute lung inflammation
    Abraham, E
    Arcaroli, J
    Carmody, A
    Wang, HC
    Tracey, KJ
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (06) : 2950 - 2954
  • [2] The clinical pathology of severe acute respiratory syndrome (SARS): a report from China
    Ding, YQ
    Wang, HJ
    Shen, H
    Li, ZG
    Geng, J
    Han, HX
    Cai, JJ
    Li, X
    Kang, W
    Weng, DS
    Lu, YD
    Wu, DH
    He, L
    Yao, KT
    [J]. JOURNAL OF PATHOLOGY, 2003, 200 (03) : 282 - 289
  • [3] Lung pathology of severe acute respiratory syndrome (SARS): A study of 8 autopsy cases from Singapore
    Franks, TJ
    Chong, PY
    Chui, P
    Galvin, JR
    Lourens, RM
    Reid, AH
    Selbs, E
    McEvoy, PL
    Hayden, DL
    Fukuoka, J
    Taubenberger, JK
    Travis, WD
    [J]. HUMAN PATHOLOGY, 2003, 34 (08) : 743 - 748
  • [4] Is traditional Chinese medicine useful in the treatment of SARS?
    Jia, W
    Gao, WY
    [J]. PHYTOTHERAPY RESEARCH, 2003, 17 (07) : 840 - 841
  • [5] Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
    Kokkola, R
    Li, J
    Sundberg, E
    Aveberger, AC
    Palmblad, K
    Yang, H
    Tracey, KJ
    Andersson, U
    Harris, HE
    [J]. ARTHRITIS AND RHEUMATISM, 2003, 48 (07): : 2052 - 2058
  • [6] High mobility group box chromosomal protein 1 - A novel proinflammatory mediator in synovitis
    Kokkola, R
    Sundberg, E
    Ulfgren, AK
    Palmblad, K
    Li, J
    Wang, H
    Ulloa, L
    Yang, H
    Yan, XJ
    Furie, R
    Chiorazzi, N
    Tracey, KJ
    Andersson, U
    Harris, HE
    [J]. ARTHRITIS AND RHEUMATISM, 2002, 46 (10): : 2598 - 2603
  • [7] Lang ZW, 2003, CHINESE MED J-PEKING, V116, P976
  • [8] High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis
    Pullerits, R
    Jonsson, IM
    Verdrengh, M
    Bokarewa, M
    Anderson, U
    Erlandsson-Harris, H
    Tarkowski, A
    [J]. ARTHRITIS AND RHEUMATISM, 2003, 48 (06): : 1693 - 1700
  • [9] IFN-γ induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Rendon-Mitchell, B
    Ochani, M
    Li, JH
    Hang, JL
    Wang, H
    Yang, H
    Susarla, S
    Czura, C
    Mitchell, RA
    Chen, GQ
    Sama, AE
    Tracey, KJ
    Wang, HC
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (07) : 3890 - 3897
  • [10] Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    Scaffidi, P
    Misteli, T
    Bianchi, ME
    [J]. NATURE, 2002, 418 (6894) : 191 - 195
12