Preparation and characterization of manganese ferrite-based magnetic liposomes for hyperthermia treatment of cancer

被引：84
作者：
Pradhan, Pallab
Giri, Jyotsnendu
Banerjee, Rinti
Bellare, Jayesh
Bahadur, Dhirendra [1 ]
机构：
[1] Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
[2] Sch Biosci & Bioengn, Bombay, Maharashtra, India
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期
关键词：
magnetic fluid; magnetic liposome; thin film hydration; heating ability; cytocompatibility;
D O I：
10.1016/j.jmmm.2006.10.1179
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Comparative evaluation of two different methods of magnetic liposomes preparation, namely thin film hydration (TFH) and double emulsion (DE) with different molar ratios of egg-phosphatidyl choline (egg-PC) and cholesterol using lauric acid coated manganese ferrite-based aqueous magnetic fluid, is reported. TFH was found to be a better method of encapsulation and TFH 2:1 (egg-PC: cholesterol) magnetic liposomes showed the highest encapsulation efficiency and comparable heating ability to that of magnetic fluids. Stealth TFH 2:1 magnetic liposomes containing DSPE-PEG(2000) were three-fold more cytocompatible as compared to the magnetic fluid. Stealth TFH 2:1 manganese ferrite-based magnetic liposomes might be useful for hyperthermia treatment of cancer. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：208 / 215
页数：8
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