Recent Advances on the Green Synthesis and Antioxidant Activities of Pyrazoles

被引:25
作者
Dias, Daiane [1 ]
Pacheco, Bruna S. [2 ]
Cunico, Wilson [2 ]
Pizzuti, Lucas [3 ]
Pereira, Claudio M. P. [2 ,4 ]
机构
[1] Fundacao Univ Fed Rio Grande, Chem & Food Sch, BR-96203900 Rio Grande, RS, Brazil
[2] Univ Fed Pelotas, Postgrad Program Biochem & Bioprospect, Pelotas, RS, Brazil
[3] Fed Univ Grande Dourados, Mato Grosso, MS, Brazil
[4] Univ Fed Pelotas, Lab Lipid & Bioorgan, Pelotas, RS, Brazil
关键词
Antioxidant activities; green chemistry; pyrazoles; ANTI-HCV; DERIVATIVES; ANTITUMOR; ANTIMICROBIALS; DESIGN; BIS;
D O I
10.2174/1389557515666150101102606
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Pyrazoles have a representative history in medicinal chemistry. These nucleuses, molecules of synthetic origin, constitute a group of nitrogen heterocyclic compounds. Available literature particularly shows a variety of pyrazoles with antioxidant effect. In this connection, this review describes the advances on the green synthesis of pyrazoles with antioxidant activity, mainly covering the data published over the last seven years (2008-2014).
引用
收藏
页码:1078 / 1092
页数:15
相关论文
共 41 条
[1]   Synthesis and screening of anti-cancer, antioxidant, and anti-inflammatory activities of novel galloyl pyrazoline derivatives [J].
Abdel-Aziz, Mohamed ;
Gamal-Eldeen, Amira M. .
PHARMACEUTICAL BIOLOGY, 2009, 47 (09) :854-863
[2]   Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2'-thienyl)pyrazole-based heterocycles [J].
Abdel-Wahab, Bakr F. ;
Abdel-Gawad, Hassan ;
Awad, Ghada E. A. ;
Badria, Farid A. .
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (07) :1418-1426
[3]   Synthesis, Molecular Structure and Antioxidant Activity of (E)-4-[Benzylideneamino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, a Schiff Base Ligand of 4-Aminoantipyrine [J].
Alam, Mohammad Sayed ;
Lee, Dong-Ung .
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2012, 42 (02) :93-102
[4]   Design, synthesis, characterization and biological evaluation of novel pyrazole integrated benzophenones [J].
Bandgar, Babasaheb P. ;
Chavan, Hemant V. ;
Adsul, Laxman K. ;
Thakare, Vishnu N. ;
Shringare, Sadanand N. ;
Shaikh, Rafik ;
Gacche, Rajesh N. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (03) :912-916
[5]   Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents [J].
Bandgar, Babasaheb P. ;
Gawande, Shrikant S. ;
Bodade, Ragini G. ;
Gawande, Nalini M. ;
Khobragade, Chandrahasya N. .
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (24) :8168-8173
[6]   Synthesis and Antioxidant Activity of Bis and Tris Heterocycles [J].
Basha, Nabhubygari Mahaboob ;
Seenaiah, Dandu ;
Padmaja, Adivireddy ;
Padmavathi, Venkatapuram ;
Bhargav, Desaraju Suresh ;
Vijaya, Tartte .
ARCHIV DER PHARMAZIE, 2014, 347 (01) :54-67
[7]   Density Functional Theory (DFT) Study of Edaravone Derivatives as Antioxidants [J].
Borges, Rosivaldo S. ;
Queiroz, Auriekson N. ;
Mendes, Anna P. S. ;
Araujo, Sanderson C. ;
Franca, Luiz C. S. ;
Franco, Edna C. S. ;
Leal, Walace G. ;
da Silva, Alberico B. F. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (06) :7594-7606
[8]   What is a green solvent?: A comprehensive framework for the environmental assessment of solvents [J].
Capello, Christian ;
Fischer, Ulrich ;
Hungerbuehler, Konrad .
GREEN CHEMISTRY, 2007, 9 (09) :927-934
[9]   Organic Synthesis "On Water" [J].
Chanda, Arani ;
Fokin, Valery V. .
CHEMICAL REVIEWS, 2009, 109 (02) :725-748
[10]   Ultrasound promoted green synthesis of spiro[pyrano[2,3-c]pyrazoles] as antioxidant agents [J].
Dandia, Anshu ;
Saini, Deepti ;
Bhaskaran, Sumit ;
Saini, Dinesh Kumar .
MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (02) :725-734