Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water

被引：14
|
作者：
Kong, Dulin [1 ,2 ]
Wang, Qinghe [3 ]
Zhu, Zhongxiang [3 ]
Wang, Xianghui [3 ]
Shi, Zaifeng [3 ]
Lin, Qiang [2 ,3 ]
Wu, Mingshu [3 ]
机构：
[1] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571199, Hainan Province, Peoples R China
[2] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Jiangsu, Peoples R China
[3] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 27期
关键词：
2-Thiobarbituric acid; 8-Quinolinol; Synthesis; Water; ORGANIC-SYNTHESIS;
D O I：
10.1016/j.tetlet.2017.05.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, three-component condensation reaction of 8-quinolinol, 2-thiobarbituric acid and isatins or aldehydes in water to give novel barbituroquinoline derivatives for the first time, is described. The reaction is free of catalysts and toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2644 / 2647
页数：4
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