Biomolecules in cell-derived extracellular vesicle chariots as warriors to repair damaged tissues

被引：11

作者：

Guo, Yingshu ^{[1
]}

Wu, Di ^{[2
]}

Zhang, Xu ^{[1
]}

Zhang, Kaixiang ^{[3
]}

Luo, Yang ^{[4
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Sch Chem & Chem Engn, Shandong Prov Key Lab Mol Engn, Jinan 250353, Peoples R China

[2] Linyi Univ, Sch Chem & Chem Engn, Linyi 276005, Shandong, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[4] Chongqing Univ, Sch Med, Ctr Smart Lab & Mol Med, Chongqing 400044, Peoples R China

来源：

NANOSCALE | 2021年 / 13卷 / 38期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; WOUND REPAIR; EXOSOMES; ANGIOGENESIS; MICRORNAS; PROMOTE; BIOGENESIS; MODULATION; PROTEINS; PROGRESS;

D O I：

10.1039/d1nr04999b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this review, we highlight the innovative applications of biomolecules from parent cell-derived extracellular vesicles (EVs) for tissue repair that have been developed in recent years. We evaluate the underlying mechanisms and therapeutic efficacy of each therapy. In previous literature reviews, it was most common to classify the use of EVs in tissue repair by disease type. This article reviews the role of three biomolecules in EVs in tissue repair. This review first summarizes the definitions and classifications of EVs. Then, the importance and significance of treating tissue damage with EVs are discussed. In particular, EV contents for tissue repair are three main types of biomolecules: proteins, RNAs and cell growth factors. The therapeutic and repair mechanisms of the biomolecules are discussed respectively. Finally, the development prospect and potential challenges of EV contents from highly differentiated cells as specific agents for tissue repair are summarized. When EVs are used to treat diseases such as tissue or organ damage, EVs play a role in delivery, and the real repair effect is effected by the various biomolecules carried by EVs. We believe that EV biomolecules have unparalleled advantages and clinical transformation potential for tissue repair and expect this review to inspire more intensive research work in this field.

引用

页码：16017 / 16033

页数：17

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