Animal models of head and neck squamous cell carcinoma

被引：72
作者：
Supsavhad, Wachiraphan [1 ]
Dirksen, Wessel P. [1 ]
Martin, Chelsea K. [2 ]
Rosol, Thomas J. [1 ]
机构：
[1] Ohio State Univ, Coll Vet Med, Dept Vet Biosci, 1925 Coffey Rd, Columbus, OH 43210 USA
[2] Univ Prince Edward Isl, Dept Pathol & Microbiol, Atlantic Vet Coll, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada
来源：
VETERINARY JOURNAL | 2016年 / 210卷
关键词：
Animal model; Head and neck squamous cell carcinoma; Feline oral squamous cell carcinoma; PAPILLOMAVIRAL DNA-SEQUENCES; UPPER AERODIGESTIVE TRACT; GROWTH-FACTOR RECEPTOR; IN-SITU; MOUSE MODEL; ORAL-CANCER; P53; EXPRESSION; BONE INVASION; FELINE HEAD; HISTORICAL-PERSPECTIVE;
D O I：
10.1016/j.tvjl.2015.11.006
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Head and neck squamous cell carcinoma (HNSCC) is the most common oral cancer worldwide. Local bone invasion into the maxilla or mandible and metastasis to regional lymph nodes often result in a poor prognosis, decreased quality of life and shortened survival time for HNSCC patients. Poor response to treatment and clinical outcomes are the major concerns in this aggressive cancer. Multiple animal models have been developed to replicate spontaneous HNSCC and investigate genetic alterations and novel therapeutic targets. This review provides an overview of HNSCC as well as the traditional animal models used in HNSCC pre-clinical research. The value and challenges of each in vivo model are discussed. Similarity between HNSCC in humans and cats and the possibility of using spontaneous feline oral squamous cell carcinoma (FOSCC) as a model for HNSCC in translational research are highlighted. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7 / 16
页数：10
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