New functions for an old variant: no substitute for histone H3.3

被引：127
|
作者：
Elsaesser, Simon J. [1 ]
Goldberg, Aaron D. [1 ]
Allis, C. David [1 ]
机构：
[1] Rockefeller Univ, Lab Chromatin Biol, New York, NY 10065 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期
关键词：
SACCHAROMYCES-CEREVISIAE; CHROMATIN-STRUCTURE; ACTIVE CHROMATIN; MESSENGER-RNA; FISSION YEAST; DNA-SYNTHESIS; CELL-CYCLE; IN-VIVO; GENES; REPLICATION;
D O I：
10.1016/j.gde.2010.01.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Histone proteins often come in different variants serving specialized functions in addition to their fundamental role in packaging DNA. The metazoan histone H3.3 has been most closely associated with active transcription. Its role in histone replacement at active genes and promoters is conserved to the single histone H3 in yeast. However, recent genetic studies in flies have challenged its importance as a mark of active chromatin, and revealed unexpected insights into essential functions of H3.3 in the germline. With strikingly little. amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes.
引用
收藏
页码：110 / 117
页数：8
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