Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

被引：48

作者：

Bedin, Anne-Sophie ^{[1
]}

Makinson, Alain ^{[2
,3
]}

Picot, Marie-Christine ^{[4
,5
]}

Mennechet, Frank ^{[1
]}

Malergue, Fabrice ^{[6
]}

Pisoni, Amandine ^{[1
,7
]}

Nyiramigisha, Esperance ^{[7
]}

Montagnier, Lise ^{[7
]}

Bollore, Karine ^{[1
]}

Debiesse, Segolene ^{[1
]}

Morquin, David ^{[3
]}

Veyrenche, Nicolas ^{[7
]}

Renault, Constance ^{[1
]}

Foulongne, Vincent ^{[1
,7
]}

Bret, Caroline ^{[8
]}

Bourdin, Arnaud ^{[9
,10
]}

Le Moing, Vincent ^{[2
,3
]}

Van de Perre, Philippe ^{[1
,7
]}

Tuaillon, Edouard ^{[1
,7
]}

机构：

[1] Montpellier Univ, EFS, INSERM, Pathogenesis & Control Chron Infect, Montpellier, France

[2] Montpellier Univ, INSERM U1175 IRD UMI 233, IRD, Montpellier, France

[3] Montpellier Univ Hosp, Dept Infect Dis, Montpellier, France

[4] Montpellier Univ, Ctr Invest Clin 1411, INSERM, Montpellier, France

[5] Montpellier Univ Hosp, Montpellier, France

[6] Immunotech Beckman Coulter, Dept Res & Dev, Marseille, France

[7] Montpellier Univ Hosp, Lab Virol, Montpellier, France

[8] Montpellier Univ Hosp, Lab Hematol, Montpellier, France

[9] Montpellier Univ Hosp, Dept Resp Dis, Montpellier, France

[10] Montpellier Univ, INSERM, CNRS, PhyMedExp, Montpellier, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 04期

关键词：

CD169; COVID-19; monocytes; SARS-CoV-2; viral infections; INFECTION;

D O I：

10.1093/infdis/jiaa724

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

引用

页码：562 / 567

页数：6

共 15 条

[1]

Aschenbrenner AC, DIS SEVERITY SPECIFI, DOI [10.1101/2020.07.07.201483, DOI 10.1101/2020.07.07.201483]

[2]

Bourgoin P, CD64 CD169 COULD HEL, DOI [10.1101/2020.10.28.20221259, DOI 10.1101/2020.10.28.20221259]

[3] Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department [J].

Bourgoin, Penelope ;

Lediagon, Guillaume ;

Arnoux, Isabelle ;

Bernot, Denis ;

Morange, Pierre-Emmanuel ;

Michelet, Pierre ;

Malergue, Fabrice ;

Markarian, Thibaut .

FUTURE MICROBIOLOGY, 2020, 15 (03) :189-201

[4] Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 [J].

Carissimo, Guillaume ;

Xu, Weili ;

Kwok, Immanuel ;

Abdad, Mohammad Yazid ;

Chan, Yi-Hao ;

Fong, Siew-Wai ;

Puan, Kia Joo ;

Lee, Cheryl Yi-Pin ;

Yeo, Nicholas Kim-Wah ;

Amrun, Siti Naqiah ;

Chee, Rhonda Sin-Ling ;

How, Wilson ;

Chan, Stephrene ;

Fan, Bingwen Eugene ;

Andiappan, Anand Kumar ;

Lee, Bernett ;

Roetzschke, Olaf ;

Young, Barnaby Edward ;

Leo, Yee-Sin ;

Lye, David Chien ;

Renia, Laurent ;

Ng, Lai Guan ;

Larbi, Anis ;

Ng, Lisa F. P. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[5]

Chevrier S, DISTINCT INNATE IMMU, DOI [10.1101/2020.08.04.236315., DOI 10.1101/2020.08.04.236315]

[6] Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients [J].

Hadjadj, Jerome ;

Yatim, Nader ;

Barnabei, Laura ;

Corneau, Aurelien ;

Boussier, Jeremy ;

Smith, Nikaia ;

Pere, Helene ;

Charbit, Bruno ;

Bondet, Vincent ;

Chenevier-Gobeaux, Camille ;

Breillat, Paul ;

Carlier, Nicolas ;

Gauzit, Remy ;

Morbieu, Caroline ;

Pene, Frederic ;

Marin, Nathalie ;

Roche, Nicolas ;

Szwebel, Tali-Anne ;

Merkling, Sarah H. ;

Treluyer, Jean-Marc ;

Veyer, David ;

Mouthon, Luc ;

Blanc, Catherine ;

Tharaux, Pierre-Louis ;

Rozenberg, Flore ;

Fischer, Alain ;

Duffy, Darragh ;

Rieux-Laucat, Frederic ;

Kerneis, Solen ;

Terrier, Benjamin .

SCIENCE, 2020, 369 (6504) :718-+

[7]

Kim WK, 2015, AIDS RES HUM RETROV, V31, P696, DOI [10.1089/AID.2015.0003, 10.1089/aid.2015.0003]

[8]

Michel M, ULTRASENSITIVE ULTRA, DOI [10.1101/2020.10.22.20215749, DOI 10.1101/2020.10.22.20215749]

[9] Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection [J].

Michlmayr, Daniela ;

Kim, Eun-Young ;

Rahman, Adeeb H. ;

Raghunathan, Rohit ;

Kim-Schulze, Seunghee ;

Che, Yan ;

Kalayci, Selim ;

Gumus, Zeynep H. ;

Kuan, Guillermina ;

Balmaseda, Angel ;

Kasarskis, Andrew ;

Wolinsky, Steven M. ;

Suarez-Farinas, Mayte ;

Harris, Eva .

CELL REPORTS, 2020, 31 (04)

[10]

Roussel M, MASS CYTOMETRY ARTI, DOI [10.1101/2020.09.22.307975, DOI 10.1101/2020.09.22.307975]

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