COVID-19 vaccine challenges: What have we learned so far and what remains to be done?

被引:153
作者
Forman, Rebecca [1 ]
Shah, Soleil [2 ]
Jeurissen, Patrick [3 ,4 ]
Jit, Mark [5 ]
Mossialos, Elias [1 ,6 ]
机构
[1] London Sch Econ & Polit Sci, London, England
[2] Stanford Univ, Sch Med, Stanford, CA USA
[3] Radboud Univ Nijmegen, Sci Inst Qual Healthcare, Med Ctr, Nijmegen, Netherlands
[4] Minist Hlth Welf & Sport, The Hague, Netherlands
[5] London Sch Hyg & Trop Med, London, England
[6] Imperial Coll London, London, England
关键词
OPTIONS MARKET; ACCESS;
D O I
10.1016/j.healthpol.2021.03.013
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Developing and distributing a safe and effective SARS-CoV-2 (COVID-19) vaccine has garnered immense global interest. Less than a year after COVID-19 was declared a pandemic, several vaccine candidates had received emergency use authorization across a range of countries. Despite this scientific breakthrough, the journey from vaccine discovery to global herd immunity against COVID-19 continues to present significant policy challenges that require a collaborative, global response. We offer a framework for understanding remaining and new policy challenges for successful global vaccine campaigns against COVID-19 as well as potential solutions to address them. Decision-makers must be aware of these challenges and strategize solutions that can be implemented at scale. These include challenges around maintaining R&D incentives, running clinical trials, authorizations, post-market surveillance, manufacturing and supply, global dissemination, allocation, uptake, and clinical system adaption. Alongside these challenges, financial and ethical concerns must also be addressed. (C) 2021 The Author(s). Published by Elsevier B.V.
引用
收藏
页码:553 / 567
页数:15
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