Osteoporosis and fractures in women: the burden of disease

被引:117
作者
Lorentzon, M. [1 ,2 ,3 ]
Johansson, H. [1 ,3 ]
Harvey, N. C. [4 ,5 ,6 ]
Liu, E. [1 ]
Vandenput, L. [1 ,3 ]
McCloskey, E. V. [7 ,8 ]
Kanis, J. A. [3 ,7 ]
机构
[1] Univ Gothenburg, Inst Med, Sahlgrenska Osteoporosis Ctr, Dept Internal Med & Clin Nutr, Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Reg Vastra Gotaland, Dept Geriatr Med, Molndal, Sweden
[3] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia
[4] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England
[5] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England
[6] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
[7] Univ Sheffield, Sch Med, Ctr Metab Bone Dis, Sheffield, S Yorkshire, England
[8] Univ Sheffield, Mellanby Ctr Bone Res, MRC & Arthrit Res, UK Ctr Integrated Res Musculoskeletal Ageing, Sheffield, S Yorkshire, England
基金
英国医学研究理事会;
关键词
Osteoporosis; fracture; postmenopausal; epidemiology; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; HIP FRACTURE; VERTEBRAL FRACTURES; NONVERTEBRAL FRACTURES; RISK-FACTOR; PREVENTION; ALENDRONATE; MANAGEMENT; DIAGNOSIS;
D O I
10.1080/13697137.2021.1951206
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Osteoporosis is a disease characterized by impaired bone microarchitecture and reduced bone mineral density (BMD) resulting in bone fragility and increased risk of fracture. In western societies, one in three women and one in five men will sustain an osteoporotic fracture in their remaining lifetime from the age of 50 years. Fragility fractures, especially of the spine and hip, commonly give rise to increased morbidity and mortality. In the five largest European countries and Sweden, fragility fractures were the cause of 2.6 million disability-adjusted life years in 2016 and the fracture-related costs increased from euro29.6 billion in 2010 to euro37.5 billion in 2017. In the European Union and the USA, only a small proportion of women eligible for pharmacological treatment are being prescribed osteoporosis medication. Secondary fracture prevention, using Fracture Liaison Services, can be used to increase the rates of fracture risk assessment, BMD testing and use of osteoporosis medication in order to reduce fracture numbers. Additionally, established primary prevention strategies, based on case-finding methods utilizing fracture prediction tools, such as FRAX, to identify women without fracture but with elevated risk, are recommended in order to further reduce fracture numbers.
引用
收藏
页码:4 / 10
页数:7
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