Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury

被引:19
作者
Song, Sung Hwa [1 ]
Kim, Ji Eun [1 ]
Sung, Ji Eun [1 ]
Lee, Hyun Ah [1 ]
Yun, Woo Bin [1 ]
Lee, Young Hee [2 ]
Song, HyunKeun [3 ]
Hwang, DaeYoun [1 ]
机构
[1] Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Biomat Sci, Life & Ind Convergence Res Inst, Miryang 627706, South Korea
[2] Pusan Natl Univ, Dept Organ Mat Sci & Engn, Busan 609735, South Korea
[3] INJE Univ, Dept Microbiol & Immunol, Coll Med, 633-165 GaegumDong, Busan 614735, South Korea
来源
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE | 2019年 / 9卷 / 04期
关键词
Gallarhois; Anti-gastric ulcer; Antioxidant; Toxicity; Animal model;
D O I
10.1016/j.jtcme.2017.07.001
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Gallarhois (GR) is a traditional oriental herbal medicine with various pharmacological effects; however, its effect on gastric ulcer has not been previously explored. We firstly investigated the component and antioxidant activity of GR extract (EtGR) by HPLC analysis and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The results showed that EtGR consisted of gallotannin (68.7%), gallic acid (27.2%) and methyl gallate (4.1%) and that it had a high antioxidant value (IC50 value; 1.93 mu g/mL). To evaluate the possible anti-gastric ulcer potential of EtGR, we investigated the effects of EtGR in the model of ethanol/hydrochloric acid (EtOH/HCl)-induced gastric ulcer. Gross and histological gastric lesions, biochemical and gene expression parameters were taken into consideration. The results showed that EtOH/HCl treatment produced mucosal injuries with morphological and histological damage, whereas EtGR co-treatment reduced the gastric injuries. EtGR treatment also decreased the contents of malonaldehyde (MDA) activity relative to the vehicle group. Moreover, EtGR decreased the levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and cyclo-oxygenase-2 (COX-2) expression. Finally, EtGR did not induce any specific toxicity in the livers or kidneys of the EtOH/HCl-induced gastric ulcer model. These results suggest that EtGR had stronger antioxidant activity and could be a new useful natural drug for gastroprotection against gastric ulcer. Moreover, these findings provide a scientific basis for the development of drugs from traditional oriental herbal medicines. (C) 2017 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.
引用
收藏
页码:372 / 382
页数:11
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