Progression of White Matter Disease and Cortical Thinning Are Not Related in Older Community-Dwelling Subjects

被引：38

作者：

Dickie, David Alexander ^{[1
,2
,6
]}

Karama, Sherif ^{[7
,8
]}

Ritchie, Stuart J. ^{[3
,4
]}

Cox, Simon R. ^{[3
,4
]}

Sakka, Eleni ^{[1
,2
,6
]}

Royle, Natalie A. ^{[1
,2
,6
]}

Aribisala, Benjamin S. ^{[1
,2
,6
]}

Hernandez, Maria Valdes ^{[1
,2
,6
]}

Maniega, Susana Munoz ^{[1
,2
,6
]}

Pattie, Alison ^{[3
]}

Corley, Janie ^{[3
]}

Starr, John M. ^{[4
]}

Bastin, Mark E. ^{[1
,2
,4
,6
]}

Evans, Alan C. ^{[7
]}

Deary, Ian J. ^{[3
,4
]}

Wardlaw, Joanna M. ^{[1
,2
,4
,5
,6
]}

机构：

[1] Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Univ Edinburgh, Neuroimaging Sci, Ctr Clin Brain Sci, Edinburgh EH16 4TJ, Midlothian, Scotland

[3] Univ Edinburgh, Dept Psychol, Edinburgh EH16 4TJ, Midlothian, Scotland

[4] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH16 4TJ, Midlothian, Scotland

[5] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH16 4TJ, Midlothian, Scotland

[6] Scottish Imaging Network, Edinburgh, Midlothian, Scotland

[7] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada

[8] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada

来源：

STROKE | 2016年 / 47卷 / 02期

基金：

英国医学研究理事会;

关键词：

ageing; brain; cortex; MRI; white matter hyperintensities; COGNITIVE-ABILITY; MRI DATA; HYPERINTENSITIES; LESIONS; AGE; ASSOCIATION; THICKNESS; VOLUME; RISK;

D O I：

10.1161/STROKEAHA.115.011229

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-We assessed cross-sectional and longitudinal relationships between whole brain white matter hyperintensity (WMH) volume and regional cortical thickness. Methods-We measured WMH volume and regional cortical thickness on magnetic resonance imaging at approximate to 73 and approximate to 76 years in 351 community-dwelling subjects from the Lothian Birth Cohort 1936. We used multiple linear regression to calculate cross-sectional and longitudinal associations between regional cortical thickness and WMH volume controlling for age, sex, Mini Mental State Examination, education, intelligence quotient at age 11, and vascular risk factors. Results-We found cross-sectional associations between WMH volume and cortical thickness within and surrounding the Sylvian fissure at 73 and 76 years (rho=-0.276, Q=0.004). However, we found no significant longitudinal associations between (1) baseline WMH volume and change in cortical thickness; (2) baseline cortical thickness and change in WMH volume; or (3) change in WMH volume and change in cortical thickness. Conclusions-Our results show that WMH volume and cortical thinning both worsen with age and are associated cross-sectionally within and surrounding the Sylvian fissure. However, changes in WMH volume and cortical thinning from 73 to 76 years are not associated longitudinally in these relatively healthy older subjects. The underlying cause(s) of WMH growth and cortical thinning have yet to be fully determined.

引用

页码：410 / 416

页数：7

共 33 条

[21] Progression of cerebral white matter lesions: 6-year results of the Austrian Stroke Prevention Study [J].

Schmidt, R ;

Enzinger, C ;

Ropele, S ;

Schmidt, H ;

Fazekas, F .

LANCET, 2003, 361 (9374) :2046-2048

[22] Mapping cortical change across the human life span [J].

Sowell, ER ;

Peterson, BS ;

Thompson, PM ;

Welcome, SE ;

Henkenius, AL ;

Toga, AW .

NATURE NEUROSCIENCE, 2003, 6 (03) :309-315

[23]

Thompson PM, 2003, J NEUROSCI, V23, P994

[24] Relationship Between White Matter Hyperintensities, Cortical Thickness, and Cognition [J].

Tuladhar, Anil M. ;

Reid, Andrew T. ;

Shumskaya, Elena ;

de Laat, Karlijn F. ;

van Norden, Anouk G. W. ;

van Dijk, Ewoud J. ;

Norris, David G. ;

de Leeuw, Frank-Erik .

STROKE, 2015, 46 (02) :425-432

[25] New multispectral MRI data fusion technique for white matter lesion segmentation: method and comparison with thresholding in FLAIR images [J].

Valdes Hernandez, Maria del C. ;

Ferguson, Karen J. ;

Chappell, Francesca M. ;

Wardlaw, Joanna M. .

EUROPEAN RADIOLOGY, 2010, 20 (07) :1684-1691

[26] Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure [J].

Veldink, JH ;

Scheltens, P ;

Jonker, C ;

Launer, LJ .

NEUROLOGY, 1998, 51 (01) :319-320

[27] Fiber tract-based atlas of human white matter anatomy [J].

Wakana, S ;

Jiang, HY ;

Nagae-Poetscher, LM ;

van Zijl, PCM ;

Mori, S .

RADIOLOGY, 2004, 230 (01) :77-87

[28] How Much Do Focal Infarcts Distort White Matter Lesions and Global Cerebral Atrophy Measures? [J].

Wang, Xin ;

Hernandez, Maria C. Valdes ;

Doubal, Fergus ;

Chappell, Francesca M. ;

Wardlaw, Joanna M. .

CEREBROVASCULAR DISEASES, 2012, 34 (5-6) :336-342

[29] Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities [J].

Wardlaw, Joanna M. ;

Allerhand, Michael ;

Doubal, Fergus N. ;

Hernandez, Maria Valdes ;

Morris, Zoe ;

Gow, Alan J. ;

Bastin, Mark ;

Starr, John M. ;

Dennis, Martin S. ;

Deary, Ian J. .

NEUROLOGY, 2014, 82 (15) :1331-1338

[30] Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J].

Wardlaw, Joanna M. ;

Smith, Eric E. ;

Biessels, Geert J. ;

Cordonnier, Charlotte ;

Fazekas, Franz ;

Frayne, Richard ;

Lindley, Richard I. ;

O'Brien, John T. ;

Barkhof, Frederik ;

Benavente, Oscar R. ;

Black, Sandra E. ;

Brayne, Carol ;

Breteler, Monique ;

Chabriat, Hugues ;

DeCarli, Charles ;

de Leeuw, Frank-Erik ;

Doubal, Fergus ;

Duering, Marco ;

Fox, Nick C. ;

Greenberg, Steven ;

Hachinski, Vladimir ;

Kilimann, Ingo ;

Mok, Vincent ;

van Oostenbrugge, Robert ;

Pantoni, Leonardo ;

Speck, Oliver ;

Stephan, Blossom C. M. ;

Teipel, Stefan ;

Viswanathan, Anand ;

Werring, David ;

Chen, Christopher ;

Smith, Colin ;

van Buchem, Mark ;

Norrving, Bo ;

Gorelick, Philip B. ;

Dichgans, Martin .

LANCET NEUROLOGY, 2013, 12 (08) :822-838

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